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Semin Thromb Hemost 2014; 40(06): 669-674
DOI: 10.1055/s-0034-1387882
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Inflammatory Response and Thrombosis in Older Individuals

Jeffrey Schlaudecker
1   Office of Geriatric Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio
,
Richard Becker
2   Division of Cardiovascular Health and Disease, Heart, Lung, and Vascular Institute, University of Cincinnati College of Medicine, Cincinnati, Ohio
› Author Affiliations
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Publication History

Publication Date:
24 August 2014 (online)

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Abstract

The available evidence suggests that immunosenescence induces organismal proinflammatory responses. The chronic inflammation seen in advancing age stratifies persons into aging phenotypes. Even with adjustment for confounders, elevated inflammatory cytokines significantly decrease the odds of successful aging. This chronic inflammation seen in advancing age has varied causes, including comorbid illness, adipose tissue mass, diet, socioeconomic status, body mass index, gender, age, and physical activity. Aging can therefore be thought of as an acquired thrombophilia of increasing inflammation, impaired fibrinolytic potential, and a hypercoagulable state, out of proportion to physiological needs. Factors ranging from genetic to environmental contribute to the prothrombotic tendency of aging adults, especially those with concomitant frailty, to experience a decline in health status.

Keywords

thrombosis - chronic inflammation - frailty
 

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