DPP-4 Inhibitor Teneligliptin Improves Insulin Resistance and Serum Lipid Profile in Japanese Patients with Type 2 Diabetes

M. Kusunoki; D. Sato; T. Nakamura; Y. Oshida; H. Tsutsui; Y. Natsume; K. Tsutsumi; T. Miyata

doi:10.1055/s-0034-1390419

Drug Research, Table of Contents

Drug Res (Stuttg) 2015; 65(10): 532-534
DOI: 10.1055/s-0034-1390419

Original Article

DPP-4 Inhibitor Teneligliptin Improves Insulin Resistance and Serum Lipid Profile in Japanese Patients with Type 2 Diabetes

M. Kusunoki

¹Department of Internal Medicine, Medical Clinic, Aichi Medical University, Nagoya, Japan

,

D. Sato

²Department of Biomedical Information Engineering, Graduate School of Medical Science, Yamagata University, Yamagata, Japan

,

T. Nakamura

²Department of Biomedical Information Engineering, Graduate School of Medical Science, Yamagata University, Yamagata, Japan

,

Y. Oshida

³Research Center of Health, Physical Fitness and Sports, Nagoya University, Nagoya, Japan

,

H. Tsutsui

⁴Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan

,

Y. Natsume

⁵Department of Sports Medicine, Graduate School of Medicine, Nagoya University, Nagoya, Japan

,

K. Tsutsumi

⁶Okinaka Memorial Institute for Medical Research, Tokyo, Japan

,

T. Miyata

⁷Vascular Center, Sanno Medical Center, Tokyo, Japan

› Author Affiliations

Abstract

Dipeptidyl peptidase-4 (DPP-4) inhibitors have been reported to improve the glycemic control and blood hemoglobin A_1c (HbA_1c) concentrations. However, there are few reports as yet suggesting that DPP-4 inhibitors may also improve insulin resistance and the serum lipid profile in the clinical setting. This study was aimed at investigating the effect of 14-week treatment with teneligliptin (20 mg/day) on the homeostasis model assessment ratio (HOMA-R), an indicator of insulin resistance, and serum lipid profile in 9 patients with type 2 diabetes. The treatment produced a significant decrease of the blood glucose and HbA_1c concentration (blood glucose: p=0.008; HbA_1c: p=0.038), and also improved HOMA-R (p=0.039). Furthermore, the patients showed elevation of the serum HDL-cholesterol level (p=0.032), and a tendency towards reduction of the serum triglyceride level. The results indicate that teneligliptin acts not only to improve the blood glucose control, but also to improve the insulin resistance and serum lipid profile in Japanese type 2 diabetes patients.

Key words

teneligliptin - dipeptidyl peptidase-4 inhibitor - insulin resistance - HDL-cholesterol - triglyceride

Full Text

References

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