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DOI: 10.1055/s-0034-1390481
Risks and Benefits of Carnitine Supplementation in Diabetes
Publication History
received 08 September 2014
first decision 12 September 2014
accepted 15 September 2014
Publication Date:
24 October 2014 (online)
![](https://www.thieme-connect.de/media/eced/201502/lookinside/thumbnails/10.1055-s-0034-1390481-1.jpg)
Abstract
L-carnitine is a very popular food supplement due to its safety profile, antioxidant-type activity and suggested effects on energy metabolism pathways. L-carnitine participates in both fatty acid transport pathways and the export of acetyl groups out of the mitochondria. However, contradictory data exist concerning the pharmacological outcomes of L-carnitine treatment in diabetes mellitus, which is a highly prevalent metabolic disease characterised by hyperglycemia and associated with severe complications, including cardiovascular disease and dyslipidemia. Recently, the L-carnitine-derived metabolites, acylcarnitines and trimethylamine-N-oxide, have been associated with increased cardio-metabolic risks. This review aims to highlight the possible risks and benefits of L-carnitine supplementation.
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