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Endoscopy 2015; 47(05): 457-461
DOI: 10.1055/s-0034-1390772
Innovations and brief communications
© Georg Thieme Verlag KG Stuttgart · New York

Safety and efficacy of a novel plastic stent coated with stone-dissolving agents for the treatment of biliary stones in a porcine model

Xiao Bo Cai   *
1   Department of Gastroenterology, First People’s Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China
,
Wei Xing Zhang   *
2   Department of Endoscopy, Eastern Hepatobiliary Surgery Institute/Hospital, Second Military Medical University, Shanghai, China
,
Ru Ling Zhang
1   Department of Gastroenterology, First People’s Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China
,
Xiao Dong Yuan
3   Department of Medicine II, Section Molecular Hepatology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
,
Qin Yang
4   College of Chemistry, Chemical Engineering & Biotechnology, Donghua University, Shanghai, China
,
Xiao Shen Qi
5   Department of General Surgery, First People’s Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China
,
Bai Wen Li
1   Department of Gastroenterology, First People’s Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China
,
Yue qin Qian
1   Department of Gastroenterology, First People’s Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China
,
Xing Peng Wang
1   Department of Gastroenterology, First People’s Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China
,
Lun Gen Lu
1   Department of Gastroenterology, First People’s Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China
,
Zheng Jie Xu
6   Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China
,
Xin Jian Wan
1   Department of Gastroenterology, First People’s Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China
› Author Affiliations
Further Information

Publication History

submitted 02 April 2014

accepted after revision 14 September 2014

Publication Date:
05 December 2014 (online)

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Background and study aim: We previously reported on a plastic stent that was coated with ethylenediaminetetraacetic acid (EDTA) and sodium cholate, which dissolved common bile duct (CBD) stones ex vivo. The aim of this study was to investigate the safety and efficacy of such stents on biliary stones in a live porcine model.

Methods: Stents without coating or with degradable membranes containing 0 % or 50 % EDTA and sodium cholate were inserted together with human CBD stones into the porcine CBD. Serum laboratory variables, histological examinations of the bile duct, and the weight change in stones were compared during and after stent placement for 6 months.

Results: A total of 16 pigs were included (5 no coating, 5 0 % coating, 6 50 % coating). Biliary stones showed decreased weight in all groups; however, stones in the group with 50 % coated stents showed a greater reduction in weight compared with the no coating and the 0 % coating groups (269 ± 66 mg vs. 179 ± 51 mg [P = 0.09]; 269 ± 66 mg vs. 156 ± 26 mg [P = 0.01], respectively).

Conclusions: The plastic stent coated with 50 % agent enhanced CBD stone dissolution in vivo and may be a promising tool for patients with difficult biliary stones.

* These authors contributed equally to this article.


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