Download PDF
Endoscopy 2015; 47(06): 525-528
DOI: 10.1055/s-0034-1391123
Innovations and brief communications
© Georg Thieme Verlag KG Stuttgart · New York

Magnetic-controlled capsule endoscopy vs. gastroscopy for gastric diseases: a two-center self-controlled comparative trial

Wen-Bin Zou   *
1   Digestive Endoscopy Center, Department of Gastroenterology, Shanghai Changhai Hospital, Second Military Medical University, Shanghai, China
,
Xiao-Hua Hou   *
2   Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
,
Lei Xin   *
1   Digestive Endoscopy Center, Department of Gastroenterology, Shanghai Changhai Hospital, Second Military Medical University, Shanghai, China
,
Jun Liu
2   Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
,
Lu-Min Bo
1   Digestive Endoscopy Center, Department of Gastroenterology, Shanghai Changhai Hospital, Second Military Medical University, Shanghai, China
,
Guan-Yu Yu
1   Digestive Endoscopy Center, Department of Gastroenterology, Shanghai Changhai Hospital, Second Military Medical University, Shanghai, China
,
Zhuan Liao
1   Digestive Endoscopy Center, Department of Gastroenterology, Shanghai Changhai Hospital, Second Military Medical University, Shanghai, China
,
Zhao-Shen Li
1   Digestive Endoscopy Center, Department of Gastroenterology, Shanghai Changhai Hospital, Second Military Medical University, Shanghai, China
› Author Affiliations
Further Information

Publication History

submitted 15 May 2014

accepted after revision 16 October 2014

Publication Date:
15 January 2015 (online)

Also available at
    Permissions and Reprints

Background and study aims: We developed a novel magnetic-controlled capsule endoscopy (MCE) system for use in the human stomach. The aim of the current study was to compare the diagnostic accuracy of MCE with that of standard gastroscopy for gastric diseases.

Patients and methods: A total of 68 patients were enrolled in this self-controlled trial. Patients were evaluated by both MCE and gastroscopy. Gastroscopy was performed 4 – 24 hours after completion of the MCE examination.

Results: The positive percent agreement between MCE and gastroscopy was 96.0 %, and the negative percent agreement was 77.8 %. The overall agreement was 91.2 % with a kappa value of 0.765 (P < 0.001). A total of 68 pathological findings were detected, of which 53 were identified by both methods. The MCE and standard gastroscopy missed seven and eight findings, respectively.

Conclusions: MCE showed a diagnostic accuracy similar to that of standard gastroscopy. These results suggest that MCE is a promising alternative to gastroscopy for noninvasive screening of gastric diseases.

Clinical trial registration number: NCT01903629.

* These authors contributed equally to this work.


 

  • References

  • 1 Inadomi JM, Gunnarsson CL, Rizzo JA et al. Projected increased growth rate of anesthesia professional-delivered sedation for colonoscopy and EGD in the United States: 2009 to 2015. Gastrointest Endosc 2010; 72: 580-586
    CrossrefPubMedGoogle Scholar
  • 2 Ciuti G, Menciassi A, Dario P. Capsule endoscopy: from current achievements to open challenges. IEEE Rev Biomed Eng 2011; 4: 59-72
    CrossrefPubMedGoogle Scholar
  • 3 Volke F, Keller J, Schneider A et al. In-vivo remote manipulation of modified capsule endoscopes using an external magnetic field. Gastrointest Endosc 2008; 67: AB121-AB122
    PubMedGoogle Scholar
  • 4 Keller J, Fibbe C, Volke F et al. Inspection of the human stomach using remote-controlled capsule endoscopy: a feasibility study in healthy volunteers (with videos). Gastrointest Endosc 2011; 73: 22-28
    CrossrefPubMedGoogle Scholar
  • 5 Rey JF, Ogata H, Hosoe N et al. Blinded nonrandomized comparative study of gastric examination with a magnetically guided capsule endoscope and standard video endoscope. Gastrointest Endosc 2012; 75: 373-381
    CrossrefPubMedGoogle Scholar
  • 6 Ciuti G, Donlin R, Valdastri P et al. Robotic versus manual control in magnetic steering of an endoscopic capsule. Endoscopy 2010; 42: 148-152
    Article in Thieme ConnectPubMedGoogle Scholar
  • 7 Morita E, Ohtsuka N, Shindo Y et al. In vivo trial of a driving system for a self-propelling capsule endoscope using a magnetic field (with video). Gastrointest Endosc 2010; 72: 836-840
    CrossrefPubMedGoogle Scholar
  • 8 Liao Z, Duan XD, Xin L et al. Feasibility and safety of magnetic-controlled capsule endoscopy system in examination of human stomach: a pilot study in healthy volunteers. J Interv Gastroenterol 2012; 2: 155-160
    CrossrefPubMedGoogle Scholar
  • 9 Louis TA, Lavori PW, Bailar 3rd JC et al. Crossover and self-controlled designs in clinical research. New Engl J Med 1984; 310: 24-31
    CrossrefPubMedGoogle Scholar
  • 10 Yao K. The endoscopic diagnosis of early gastric cancer. Ann Gastroenterol 2013; 26: 11-22
    PubMedGoogle Scholar
  • 11 Swain P, Toor A, Volke F et al. Remote magnetic manipulation of a wireless capsule endoscope in the esophagus and stomach of humans (with videos). Gastrointest Endosc 2010; 71: 1290-1293
    CrossrefPubMedGoogle Scholar
  • 12 Rey JF, Ogata H, Hosoe N et al. Feasibility of stomach exploration with a guided capsule endoscope. Endoscopy 2010; 42: 541-545
    Article in Thieme ConnectPubMedGoogle Scholar
  • 13 The JL, Hartman M, Lau L et al. Duration of endoscopic examination significantly impacts detection rates of neoplastic lesions during diagnostic upper endoscopy. Gastrointest Endosc 2011; 73: AB393
    PubMedGoogle Scholar
  • 14 Riccioni ME, Urgesi R, Cianci R et al. Obscure recurrent gastrointestinal bleeding: a revealed mystery?. Scand J Gastroenterol 2014; 49: 1020-1026
    CrossrefPubMedGoogle Scholar
  • 15 Neale JR, James S, Callaghan J et al. Premedication with N-acetylcysteine and simethicone improves mucosal visualization during gastroscopy: a randomized, controlled, endoscopist-blinded study. Eur J Gastroenterol Hepatol 2013; 25: 778-783
    CrossrefPubMedGoogle Scholar
  • 16 Lee SY, Han HS, Cha JM et al. Endoscopic flushing with pronase improves the quantity and quality of gastric biopsy: a prospective study. Endoscopy 2014; 46: 747-753
    Article in Thieme ConnectPubMedGoogle Scholar
  • 17 Kyriakos N, Karagiannis S, Galanis P et al. Evaluation of four time-saving methods of reading capsule endoscopy videos. Eur J Gastroenterol Hepatol 2012; 24: 1276-1280
    PubMedGoogle Scholar
  • 18 Hassan C, Zullo A, Winn S et al. Cost-effectiveness of capsule endoscopy in screening for colorectal cancer. Endoscopy 2008; 40: 414-421
    Article in Thieme ConnectPubMedGoogle Scholar