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DOI: 10.1055/s-0034-1391887
Molekularbiologie primär kutaner B-Zell-Lymphome
Molecular Biology of Cutaneous B-Cell-LymphomaPublication History
Publication Date:
23 April 2015 (online)
Zusammenfassung
Das primär kutane Keimzentrums-Lymphom und das primär kutane Marginalzonen-B-Zell-Lymphom haben eine sehr gute Prognose, wohingegen das primär kutane großzellige B-Zell-Lymphom vom Bein-Typ eine aggressivere Lymphom-Entität darstellt. In den letzten Jahren haben molekulare Studien eine Reihe von genetischen Veränderungen aufgedeckt, welche die Subgruppen der primär kutanen B-Zell-Lymphome voneinander unterscheiden. Während das primär kutane großzellige B-Zell-Lymphom vom Bein-Typ ein ähnliches Muster chromosomaler Aberrationen wie das nodale diffus-großzellige B-Zell-Lymphom hat, weisen das primär kutane Keimzentrums-Lymphom und das primär kutane Marginalzonen-B-Zell-Lymphom große Unterschiede zu dem systemischen follikulären Lymphom bzw. dem systemischen Marginalzonen-B-Zell-Lymphom vom MALT-Typ auf.
Abstract
Primary cutaneous follicle centre lymphoma (PCFCL) and primary cutaneous marginal zone B-cell lymphoma (PCMZL) have an excellent prognosis whereas primary cutaneous large B-cell lymphoma, leg type (PCLBCL, LT) represents a more aggressive lymphoma. In recent years molecular studies have revealed a series of genetic aberrations, which distinguish the subgroups of primary cutaneous B-cell lymphomas. While PCLBCL, LT display a pattern of chromosomal aberrations similar to their systemic counterpart, PCFCL and PCMZL normally lack these typical chromosomal aberrations.
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