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Planta Med 2015; 81(08): 624-629
DOI: 10.1055/s-0034-1396310
Reviews
Georg Thieme Verlag KG Stuttgart · New York

Managing Hypertension by Polyphenols

Salvador Fernández-Arroyo
1   Unitat de Recerca Biomèdica, Hospital Universitari Sant Joan, Institut dʼInvestigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Campus of International excellence Southern Catalonia, Reus, Spain
,
Jordi Camps
1   Unitat de Recerca Biomèdica, Hospital Universitari Sant Joan, Institut dʼInvestigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Campus of International excellence Southern Catalonia, Reus, Spain
,
Javier A. Menendez
2   Metabolism and Cancer Group, Translational Research Laboratory, Catalan Institute of Oncology-Girona, Molecular Oncology, Girona Biomedical Research Institute, Girona, Spain
,
Jorge Joven
1   Unitat de Recerca Biomèdica, Hospital Universitari Sant Joan, Institut dʼInvestigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Campus of International excellence Southern Catalonia, Reus, Spain
› Author Affiliations
Further Information

Publication History

received 29 July 2014
revised 15 January 2015

accepted 15 January 2015

Publication Date:
25 February 2015 (online)

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Abstract

Some polyphenols, obtained from plants of broad use, induce a favorable endothelial response in hypertension and beneficial effects in the management of other metabolic cardiovascular risks. Previous studies in our laboratories using the calyces of Hibiscus sabdariffa as a source of polyphenols show that significant effects on hypertension are noticeable in humans only when provided in high amounts. Available data are suggestive in animal models and ex vivo experiments, but data in humans are difficult to acquire. Additionally, and despite the low bioavailability of polyphenols, intervention studies provide evidence for the protective effects of secondary plant metabolites. Assumptions on public health benefits are limited by the lack of scientific knowledge, robust data derived from large randomized clinical trials, and an accurate assessment of the bioactive components provided by common foodstuff. Because it is likely that clinical effects are the result of multiple interactions among different polyphenols rather than the isolated action of unique compounds, to provide polyphenol-rich botanical extracts as dietary supplements is a suggestive option. Unfortunately, the lack of patent perspectives for the pharmaceutical industries and the high cost of production and release for alimentary industries will hamper the performance of the necessary clinical trials. Here we briefly discuss whether and how such limitations may complicate the extensive use of plant-derived products in the management of hypertension and which steps are the necessary to deal with the predictable complexity in a possible clinical practice.

Key words

Hibiscus sabdariffa - Malvaceae - botanical extracts - cardiovascular risk - hypertension - oxidation - metabolism - polyphenols

Supporting Information

 

  • References

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