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Pharmacopsychiatry 2015; 48(03): 95-103
DOI: 10.1055/s-0034-1398508
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

TPH, SLC6A2, SLC6A3, DRD2 and DRD4 Polymorphisms and Neuroendocrine Factors Predict SSRIs Treatment Outcome in the Chinese Population with Major Depression

L. Yin
1   Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan Province, People’s Republic of China
3   Li Yin and Yao Ying Zhang contributed to the work equally
,
Y. Y. Zhang
1   Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan Province, People’s Republic of China
3   Li Yin and Yao Ying Zhang contributed to the work equally
,
X. Zhang
1   Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan Province, People’s Republic of China
,
T. Yu
1   Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan Province, People’s Republic of China
2   Bio-X Institute, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, People’s Republic of China
,
G. He
2   Bio-X Institute, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, People’s Republic of China
,
X. L. Sun
1   Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan Province, People’s Republic of China
› Author Affiliations
Further Information

Publication History

received 03 October 2014
revised 07 December 2014

accepted 08 December 2014

Publication Date:
02 February 2015 (online)

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Abstract

Objective: This study was intended to determine whether antidepressant outcome to SSRIs was associated with catecholamine gene polymorphisms and neuroendocrine factors in patients of Chinese Han ethnicity with MDD.

Method: A total of 290 MDD patients were recruited and received a 6-week randomized double-blinded treatment. Cortisol, adrenocorticotropic hormone (ACTH), thyroid-stimulating hormone (TSH), 3′-triiodothyronine (T3), thyroxine (T4), free triiodothyronine (fT3), and free thyroxine (fT4) levels were measured at the baseline. Allele, genotype, and haplotype frequencies of catecholamine genes were compared between responders and non-responders, remission and non-remission groups respectively.

Results: We found that genotype frequency of the rs1800544 polymorphism in the DRD4 gene was significantly different between responders and non-responders (P<0.05). Also the frequency of the rs1800544 CG genotype was significantly higher (P<0.05) in responders (51.4%) than that in non-responders (35.8%). No significant difference was found between responders and non-responders, remission and non-remission groups in the SNPs polymorphisms in the TPH, SLC6A2, SLC6A3, or DRD2 genes. The combination of all neuroendocrine factors, clinical characteristics and gene polymorphisms predicted 74.8% of the variation in SSRI response and 65.5% in SSRI remission.

Conclusion: Polymorphisms of the DRD4 gene were associated with SSRI response in Chinese Han MDD patients. A combination of clinical characteristics, neuroendocrine factors, and gene polymorphisms might be able to predict the outcome to SSRIs.

Key words

depression - neuroendocrine factors - genes - DRD4 - pharmacogenetics
 

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