Zur Psychophysiologie exekutiver Funktionen

B. Kopp; C. Seer; F. Lange

doi:10.1055/s-0034-1398610

Klinische Neurophysiologie, Inhaltsverzeichnis

Klinische Neurophysiologie 2015; 46(01): 28-38
DOI: 10.1055/s-0034-1398610

Originalia

Zur Psychophysiologie exekutiver Funktionen

Towards a Psychophysiology of Executive Functions

B. Kopp

¹Klinik für Neurologie, Medizinische Hochschule Hannover

,

C. Seer

¹Klinik für Neurologie, Medizinische Hochschule Hannover

,

F. Lange

¹Klinik für Neurologie, Medizinische Hochschule Hannover

› Institutsangaben

Abstract

Zusammenfassung

Dieser Artikel stellt einen Versuch dar, eine Brücke zwischen klinisch manifesten Erscheinungen exekutiver Dysfunktionen, welche infolge erworbener Hirnschädigungen zu beobachten sind, und grundlagenwissenschaftlichen Studien zur Kognitiven Psychophysiologie von Exekutivfunktionen zu schlagen. Einleitend wird kurz die klinische Phänomenologie dysexekutiver Syndrome skizziert. Danach erfolgt eine Aufarbeitung kognitiver Aspekte von Exekutivfunktionen, die in eine hierarchische Taxonomie der exekutiven Kontrolle mündet. Im Anschluss daran wird eine Einführung in die Kognitive Psychophysiologie, ihre Errungenschaften und ihre (derzeitigen) Limitationen gegeben. Abschließend werden in paradigmatischer Weise am Beispiel von 2 Studien aus unserem Labor Möglichkeiten aufgezeigt, wie sich das Studium exekutiver Funktionen mit der Erhebung psychophysiologischer Messgrößen verbinden lässt.

Abstract

This review article attempts to bridge clinically manifest signs of executive dysfunctions and cognitive psychophysiological studies on executive functioning. First, the reader will be introduced to patterns of executive deficits that are commonly subsumed under the umbrella term of the dysexecutive syndrome. Cognitive aspects of executive functioning will then be clarified resulting in a hierarchical taxonomy of executive control. Subsequently, we provide an overview of the field of cognitive psychophysiology, its merits and its limitations. 2 exemplary studies from our laboratory are finally used to illustrate the possibilities associated with the combined study of executive functions and psychophysiological measures.

Schlüsselwörter

Exekutivfunktionen - Psychophysiologie - Ereigniskorrelierte Potenziale - Elektroenzephalografie - Dysexekutives Syndrom

Key words

executive functioning - psychophysiology - event-related potentials - electroencephalography - dysexecutive syndrome

Volltext

Referenzen

Literatur
1 Luria AR, Pribram KH, Homskaya ED. An experimental analysis of the behavior of disturbances produced by a left frontal arachnoidal endothelioma (meningeoma). Neuropsychologia 1964; 2: 257-280
2 Stuss DT, Benson DF. Neuropsychological studies of the frontal lobes. Psychol Bull 1984; 95: 3-28
3 Carpenter PA, Just MA, Reichle ED. Working memory and executive function: Evidence from neuroimaging. Curr Opin Neurobiol 2000; 10: 195-199
4 Lezak MD. Neuropsychological Assessment. 3^rd edn. New York: Oxford University Press; 1995
5 Diamond A. Executive functions. Annu Rev Psychol 2013; 64: 135-168
6 Jurado MB, Rosselli M. The elusive nature of executive functions: A review of our current understanding. Neuropsychol Rev 2007; 17: 213-233
7 Müller SV, Hildebrand H, Münte TF. Kognitive Therapie bei Störungen der Exekutivfunktionen. Göttingen: Hogrefe; 2004
8 Kopp B, Tabeling S, Moschner C et al. Kognitive Hirnleistungen des präfrontalen Kortex. Nervenarzt 2008; 79: 143-152
9 von Cramon DY, Schubotz RI.. Exekutivfunktionen und ihre Störungen. In: Wallesch CW. Hrsg Neurologie, Diagnostik und Therapie in Klinik und Praxis. München: Urban & Fischer; 2005: 189-198
10 Schneider W, Shiffrin RM. Controlled and automatic human information processing: I. Detection, search, and attention. Psychol Rev 1977; 84: 1-66
11 Shiffrin RM, Schneider W. Controlled and automatic human information processing: II. Perceptual learning, automatic attending and a general theory. Psychol Rev 1977; 84: 127-190
12 Descartes R. De homine figuris et latinatate donatus a Florentio Schuyl. Leyden: P Leffen & F Moyardum; 1662
13 Glimcher PW. Decisions, uncertainty, and the brain: The science of neuroeconomics. Cambridge: MIT Press; 2004
14 Nigg JT. On inhibition/disinhibition in developmental psychopathology: Views from cognitive and personality psychology and a working inhibition taxonomy. Psychol Bull 2000; 126: 220-246
15 Eriksen BA, Eriksen CW. Effects of noise letters upon the identification of a target letter in a nonsearch task. Percept Psychophys 1974; 16: 143-149
16 Meyer DE, Kieras DE. A computational theory of executive cognitive processes and multiple-task performance: Part I. Basic mechanisms. Psychol Rev 1997; 104: 3-65
17 Grange JA, Houghton G. eds. Task switching and cognitive control. New York: Oxford University Press; 2014
18 Kiesel A, Steinhauser M, Wendt M et al. Control and interference in task switching: A review. Psychol Bull 2010; 136: 849-874
19 Meiran N. Reconfiguration of processing mode prior to task performance. J Exp Psychol Learn Mem Cogn 1996; 22: 1423-1442
20 Meiran N. Task switching: Mechanisms underlying rigid vs. flexible self control. In: Hassin RR, Ochsner KN, Trope Y. eds. Self control in society, mind, and brain. New York: Oxford University Press; 2010: 202-220
21 Monsell S. Task switching. Trends Cogn Sci 2003; 7: 134-140
22 Schneider DW, Logan GD. Task switching versus cue switching: Using transition cuing to disentangle sequential effects in task-switching performance. J Exp Psychol Learn Mem Cogn 2007; 33: 370-378
23 Forstmann BU, Brass M, Koch I et al. Internally generated and directly cued task sets: An investigation with fMRI. Neuropsychologia 2005; 43: 943-952
24 West R, Langley MM, Bailey K. Signaling a switch: Neural correlates of task switching guided by task cues and transition cues. Psychophysiology 2011; 48: 612-623
25 Heaton RK, Chelune GJ, Talley JL et al. Wisconsin card sort test manual: Revised and expanded. Odessa: Psychological Assessment Resources; 1993
26 Berg EA. A simple objective technique for measuring flexibility in thinking. J Gen Psychol 1948; 39: 15-22
27 Grant DA, Berg E. A behavioral analysis of degree of reinforcement and ease of shifting to new responses in a Weigl-type card-sorting problem. J Exp Psychol 1948; 38: 404-411
28 Milner B. Effects of different brain lesions on card sorting: The role of the frontal lobes. Arch Neurol 1963; 9: 90-100
29 Demakis GJ. A meta-analytic review of the sensitivity of the Wisconsin Card Sorting Test to frontal and lateralized frontal brain damage. Neuropsychology 2003; 17: 255-264
30 Strauss E, Sherman EM, Spreen O. A compendium of neuropsychological tests: Administration, norms, and commentary. New York: Oxford University Press; 2006
31 Royall D, Lauterbach E, Cummings J et al. Executive control function: A review of its promise and challenges for clinical research. A report from the committee on research of the American Neuropsychiatric Association. J Neuropsychiatry Clin Neurosci 2002; 14: 377-406
32 Kopp B, Tabeling S, Moschner C et al. Fractionating the neural mechanisms of cognitive control. J Cogn Neurosci 2006; 18: 949-965
33 Nelson HE. A modified card sorting test sensitive to frontal lobe defects. Cortex 1976; 12: 313-324
34 Schretlen DJ. Modified Wisconsin card sorting test (M-WCST). Lutz: Psychological Assessment Resources; 2010
35 Robbins TW. Shifting and stopping: Fronto-striatal substrates, neurochemical modulation and clinical implications. Philos Trans R Soc Lond B Biol Sci 2007; 362: 917-932
36 Shallice T, Stuss DT, Picton TW et al. Mapping task switching in frontal cortex through neuropsychological group studies. Front Neurosci 2008; 2: 79-85
37 Aron AR, Robbins TW, Poldrack RA. Inhibition and the right inferior frontal cortex. Trends Cogn Sci 2004; 8: 170-177
38 Rogers RD, Monsell S. Costs of a predictable switch between simple cognitive tasks. J Exp Psychol Gen 1995; 124: 207-231
39 Shallice T, Stuss DT, Picton TW et al. Multiple effects of prefrontal lesions on task-switching. Front Hum Neurosci 2007; 1: 2
40 Badre D. Cognitive control, hierarchy, and the rostro–caudal organization of the frontal lobes. Trends Cogn Sci 2008; 12: 193-200
41 Koechlin E, Ody C, Kouneiher F. The architecture of cognitive control in the human prefrontal cortex. Science 2003; 302: 1181-1185
42 Koechlin E, Summerfield C. An information theoretical approach to prefrontal executive function. Trends Cogn Sci 2007; 11: 229-235
43 Fuster JM. The prefrontal cortex: An update. Time is of the essence. Neuron 2001; 30: 319-333
44 Suddendorf T, Corballis MC. Mental time travel and the evolution of the human mind. Genet Soc Gen Psychol Monogr 1997; 123: 133-167
45 Schacter DL, Addis DR, Buckner RL. Remembering the past to imagine the future: The prospective brain. Nat Rev Neurosci 2007; 8: 657-661
46 Weiler JA, Daum I. Mentales Zeitreisen: Neurokognitive Grundlagen des Zukunftsdenkens. Fortschr Neurol Psychiatr 2008; 76: 539-548
47 Popper K. All life is problem solving. London and New York: Taylor & Francis. : ; 1994
48 Fuster JM. Upper processing stages of the perception–action cycle. Trends Cogn Sci 2004; 8: 143-145
49 Kopp B. A simple hypothesis of executive function. Front Hum Neurosci 2012; 6: 159
50 Luck SJ. An introduction to the event-related potential technique. Cambridge: MIT Press; 2014
51 Friederici AD. Event-related brain potential studies in language. Curr Neurol Neurosci Rep 2004; 4: 466-470
52 Hillyard SA, Anllo-Vento L. Event-related brain potentials in the study of visual selective attention. Proc Natl Acad Sci USA 1998; 95: 781-787
53 Kutas M, Federmeier KD. Thirty years and counting: Finding meaning in the N400 component of the event-related brain potential (ERP). Annu Rev Psychol 2011; 62: 621-647
54 Polich J. Updating P300: An integrative theory of P3a and P3b. Clin Neurophysiol 2007; 118: 2128-2148
55 Kolossa A, Fingscheidt T, Wessel K et al. A model-based approach to trial-by-trial P300 amplitude fluctuations. Front Hum Neurosci 2012; 6: 359
56 Näätänen R, Paavilainen P, Rinne T et al. The mismatch negativity (MMN) in basic research of central auditory processing: A review. Clin Neurophysiol 2007; 118: 2544-2590
57 Friedman D, Cycowicz YM, Gaeta H. The novelty P3: An event-related brain potential (ERP) sign of the brain’s evaluation of novelty. Neurosci Biobehav Rev 2001; 25: 355-373
58 Kopp B, Lange F. Electrophysiological indicators of surprise and entropy in dynamic task-switching environments. Front Hum Neurosci 2013; 7: 300
59 Kopp B, Rist F, Mattler U. N200 in the flanker task as a neurobehavioral tool for investigating executive control. Psychophysiology 1996; 33: 282-294
60 Folstein JR, Van Petten C. Influence of cognitive control and mismatch on the N2 component of the ERP: a review. Psychophysiology 2008; 45: 152-170
61 Falkenstein M, Hohnsbein J, Hoormann J et al. Effects of crossmodal divided attention on late ERP components: II. Error processing in choice reaction tasks. Electroencephalogr Clin Neurophysiol 1991; 78: 447-455
62 Gehring WJ, Goss B, Coles MG et al. A neural system for error detection and compensation. Psychol Sci 1993; 4: 385-390
63 Kopp B, Rist F. An event-related brain potential substrate of disturbed response monitoring in paranoid schizophrenic patients. J Abnorm Psychol 1999; 108: 337-346
64 Ullsperger M, Danielmeier C, Jocham G. Neurophysiology of performance monitoring and adaptive behavior. Physiol Rev 2014; 94: 35-79
65 Ullsperger M, Fischer AG, Nigbur R et al. Neural mechanisms and temporal dynamics of performance monitoring. Trends Cogn Sci 2014; 18: 259-267
66 Knight RT. Decreased response to novel stimuli after prefrontal lesions in man. Electroencephalogr Clin Neurophysiol 1984; 59: 9-20
67 Soltani M, Knight RT. Neural origins of the P300. Crit Rev Neurobiol 2000; 14: 199-224
68 Stemmer B, Segalowitz SJ, Witzke W et al. Error detection in patients with lesions to the medial prefrontal cortex: An ERP study. Neuropsychologia 2004; 42: 118-130
69 Ullsperger M, von Cramon DY, Müller NG. Interactions of focal cortical lesions with error processing: Evidence from event-related brain potentials. Neuropsychology 2002; 16: 548-561
70 Näätänen R. Mismatch negativity: Clinical research and possible applications. Int J Psychophysiol 2003; 48: 179-188
71 Polich J. P300 clinical utility and control of variability. J Clin Neurophysiol 1998; 15: 14-33
72 Verleger R. Event-related EEG potential research in neurological patients. In: Zani A, Proverbio AM. eds. The cognitive electrophysiology of mind and brain. San Diego, London: Academic Press; 2002: 309-341
73 Polich J, Herbst K. P300 as a clinical assay: Rationale, evaluation, and findings. Int J Psychophysiol 2000; 38: 3-19
74 Ilvonen T, Kujala T, Kozou H et al. The processing of speech and non-speech sounds in aphasic patients as reflected by the mismatch negativity (MMN). Neurosci Lett 2004; 366: 235-240
75 Umbricht D, Krljes S. Mismatch negativity in schizophrenia: A meta-analysis. Schizophr Res 2005; 76: 1-23
76 Tsuchiya H, Yamaguchi S, Kobayashi S. Impaired novelty detection and frontal lobe dysfunction in Parkinson’s disease. Neuropsychologia 2000; 38: 645-654
77 Rustamov N, Rodriguez-Raecke R, Timm L et al. Absence of congruency sequence effects reveals neurocognitive inflexibility in Parkinson’s disease. Neuropsychologia 2013; 51: 2976-2987
78 Rustamov N, Rodriguez-Raecke R, Timm L et al. Attention shifting in Parkinson’s disease: An analysis of behavioral and cortical responses. Neuropsychology 2014; 28: 929-944
79 Falkenstein M, Hielscher H, Dziobek I et al. Action monitoring, error detection, and the basal ganglia: An ERP study. Neuroreport 2001; 12: 157-161
80 Holroyd CB, Praamstra P, Plat E et al. Spared error-related potentials in mild to moderate Parkinson’s disease. Neuropsychologia 2002; 40: 2116-2124
81 Ruchsow M, Grön G, Reuter K et al. Error-related brain activity in patients with obsessive-compulsive disorder and in healthy controls. J Psychophysiol 2005; 19: 298-304
82 Luck SJ, Woodman GF, Vogel EK. Event-related potential studies of attention. Trends Cogn Sci 2000; 4: 432-440
83 Ullsperger M, von Cramon DY. Ereigniskorrelierte Potenziale in der kognitiven Neurologie. Akt Neurol 2004; 31: 396-403
84 Chiappa KH. ed. Evoked potentials in clinical medicine. Philadelphia: Lippincott-Raven Publishers; 1997
85 Danielmeier C, Wessel JR, Steinhauser M et al. Modulation of the error-related negativity by response conflict. Psychophysiology 2009; 46: 1288-1298
86 Gehring WJ, Gratton G, Coles MG et al. Probability effects on stimulus evaluation and response processes. J Exp Psychol Hum Percept Perform 1992; 18: 198-216
87 Kopp B, Mattler U, Goertz R et al. N2, P3 and the lateralized readiness potential in a nogo task involving selective response priming. Electroencephalogr Clin Neurophysiol 1996; 99: 19-27
88 Yeung N, Botvinick MM, Cohen JD. The neural basis of error detection: conflict monitoring and the error-related negativity. Psychol Rev 2004; 111: 931-959
89 Gratton G, Coles MG, Donchin E. Optimizing the use of information: Strategic control of activation of responses. J Exp Psychol Gen 1992; 121: 480-506
90 Egner T. Congruency sequence effects and cognitive control. Cogn Affect Behav Neurosci 2007; 7: 380-390
91 Clayson PE, Larson MJ. Effects of repetition priming on electrophysiological and behavioral indices of conflict adaptation and cognitive control. Psychophysiology 2011; 48: 1621-1630
92 Clayson PE, Larson MJ. Conflict adaptation and sequential trial effects: Support for the conflict monitoring theory. Neuropsychologia 2011; 49: 1953-1961
93 Clayson PE, Larson MJ. Cognitive performance and electrophysiological indices of cognitive control: A validation study of conflict adaptation. Psychophysiology 2012; 49: 627-637
94 Forster SE, Carter CS, Cohen JD et al. Parametric manipulation of the conflict signal and control-state adaptation. J Cogn Neurosci 2011; 23: 923-935
95 Freitas AL, Banai R, Clark SL. When cognitive control is calibrated: Event-related potential correlates of adapting to information-processing conflict despite erroneous response preparation. Psychophysiology 2009; 46: 1226-1233
96 Larson MJ, Clayson PE, Baldwin SA. Performance monitoring following conflict: Internal adjustments in cognitive control?. Neuropsychologia 2012; 50: 426-433
97 Botvinick MM, Braver TS, Barch DM et al. Conflict monitoring and cognitive control. Psychol Rev 2001; 108: 624-652
98 Barceló F, Periáñez JA, Knight RT. Think differently: A brain orienting response to task novelty. Neuroreport 2002; 13: 1887-1892
99 Cunillera T, Fuentemilla L, Periañez J et al. Brain oscillatory activity associated with task switching and feedback processing. Cogn Affect Behav Neurosci 2012; 12: 16-33
100 Kopp B, Lange F, Howe J et al. Age-related changes in neural recruitment for cognitive control. Brain Cogn 2014; 85: 209-219
101 Barceló F, Periáñez JA, Nyhus E. An information theoretical approach to task-switching: evidence from cognitive brain potentials in humans. Front Hum Neurosci 2007; 1: 13
102 Bach DR, Dolan RJ. Knowing how much you don’t know: A neural organization of uncertainty estimates. Nat Rev Neurosci 2012; 13: 572-586
103 Fan J. An information theory account of cognitive control. Front Hum Neurosci 2014; 8: 680
104 Fleming SM, Huijgen J, Dolan RJ. Prefrontal contributions to metacognition in perceptual decision making. J Neurosci 2012; 32: 6117-6125
105 Ridderinkhof KR, Ullsperger M, Crone EA et al. The role of the medial frontal cortex in cognitive control. Science 2004; 306: 443-447
106 Kolossa A, Kopp B, Fingscheidt T. A computational analysis of the neural bases of Bayesian inference. Neuroimage 2015; 106: 222-237
107 San Martín R. Event-related potential studies of outcome processing and feedback-guided learning. Front Hum Neurosci 2012; 6: 304