Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000085.xml
Thorac Cardiovasc Surg 2016; 64(07): 596-605
DOI: 10.1055/s-0034-1399763
DOI: 10.1055/s-0034-1399763
Review Article
Risk and Complication Management in Esophageal Cancer Surgery: A Review of the Literature
Further Information
Publication History
27 January 2014
10 November 2014
Publication Date:
28 January 2015 (online)
Abstract
Esophagectomy for cancer is a highly complex and demanding two-cavity procedure associated with a considerable morbidity and mortality. There are several controversies with regard to the optimal risk and complication management. Strategies include patient selection, optimization of malnutrition, hospital and surgeon volume, intraoperative anesthesiological and surgical measures, and postoperative management of complications. In this article, we review the literature on these aspects that have an impact on outcomes after esophagectomy.
-
References
- 1 van Hagen P, Hulshof MC, van Lanschot JJ , et al; CROSS Group. Preoperative chemoradiotherapy for esophageal or junctional cancer. N Engl J Med 2012; 366 (22) 2074-2084
- 2 Sjoquist KM, Burmeister BH, Smithers BM , et al; Australasian Gastro-Intestinal Trials Group. Survival after neoadjuvant chemotherapy or chemoradiotherapy for resectable oesophageal carcinoma: an updated meta-analysis. Lancet Oncol 2011; 12 (7) 681-692
- 3 Dhungel B, Diggs BS, Hunter JG, Sheppard BC, Vetto JT, Dolan JP. Patient and peri-operative predictors of morbidity and mortality after esophagectomy: American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP), 2005-2008. J Gastrointest Surg 2010; 14 (10) 1492-1501
- 4 Saklad M. Grading of patients for surgical procedures. Anesthesiology 1941; 2: 281-284
- 5 Bartels H, Stein HJ, Siewert JR. Preoperative risk analysis and postoperative mortality of oesophagectomy for resectable oesophageal cancer. Br J Surg 1998; 85 (6) 840-844
- 6 Copeland GP. The POSSUM system of surgical audit. Arch Surg 2002; 137 (1) 15-19
- 7 Tekkis PP, McCulloch P, Poloniecki JD, Prytherch DR, Kessaris N, Steger AC. Risk-adjusted prediction of operative mortality in oesophagogastric surgery with O-POSSUM. Br J Surg 2004; 91 (3) 288-295
- 8 Noble F, Curtis N, Harris S , et al; South Coast Cancer Collaboration–Oesophago-Gastric (SC-OG). Risk assessment using a novel score to predict anastomotic leak and major complications after oesophageal resection. J Gastrointest Surg 2012; 16 (6) 1083-1095
- 9 Schröder W, Bollschweiler E, Kossow C, Hölscher AH. Preoperative risk analysis—a reliable predictor of postoperative outcome after transthoracic esophagectomy?. Langenbecks Arch Surg 2006; 391 (5) 455-460
- 10 Imdahl A, Munzar T, Schulte-Mönting J, Rückauer KD, Kirchner R, Farthmann EH. Perioperative risk factors in esophageal cancer: a retrospective study of independent variables. Zentralbl Chir 1993; 118 (4) 190-196
- 11 Grotenhuis BA, Wijnhoven BP, Grüne F, van Bommel J, Tilanus HW, van Lanschot JJ. Preoperative risk assessment and prevention of complications in patients with esophageal cancer. J Surg Oncol 2010; 101 (3) 270-278
- 12 Weimann A, Braga M, Harsanyi L , et al; DGEM (German Society for Nutritional Medicine); ESPEN (European Society for Parenteral and Enteral Nutrition). ESPEN Guidelines on Enteral Nutrition: surgery including organ transplantation. Clin Nutr 2006; 25 (2) 224-244
- 13 Rey-Ferro M, Castaño R, Orozco O, Serna A, Moreno A. Nutritional and immunologic evaluation of patients with gastric cancer before and after surgery. Nutrition 1997; 13 (10) 878-881
- 14 Norman K, Pichard C, Lochs H, Pirlich M. Prognostic impact of disease-related malnutrition. Clin Nutr 2008; 27 (1) 5-15
- 15 Pirlich M, Schütz T, Norman K , et al. The German hospital malnutrition study. Clin Nutr 2006; 25 (4) 563-572
- 16 Ligthart-Melis GC, Weijs PJ, te Boveldt ND , et al. Dietician-delivered intensive nutritional support is associated with a decrease in severe postoperative complications after surgery in patients with esophageal cancer. Dis Esophagus 2013; 26 (6) 587-593
- 17 Markar SR, Karthikesalingam A, Thrumurthy S, Low DE. Volume-outcome relationship in surgery for esophageal malignancy: systematic review and meta-analysis 2000-2011. J Gastrointest Surg 2012; 16 (5) 1055-1063
- 18 Finks JF, Osborne NH, Birkmeyer JD. Trends in hospital volume and operative mortality for high-risk surgery. N Engl J Med 2011; 364 (22) 2128-2137
- 19 Birkmeyer JD. Strategies for improving surgical quality—checklists and beyond. N Engl J Med 2010; 363 (20) 1963-1965
- 20 Ghaferi AA, Birkmeyer JD, Dimick JB. Hospital volume and failure to rescue with high-risk surgery. Med Care 2011; 49 (12) 1076-1081
- 21 Avendano CE, Flume PA, Silvestri GA, King LB, Reed CE. Pulmonary complications after esophagectomy. Ann Thorac Surg 2002; 73 (3) 922-926
- 22 Bailey SH, Bull DA, Harpole DH , et al. Outcomes after esophagectomy: a ten-year prospective cohort. Ann Thorac Surg 2003; 75 (1) 217-222 , discussion 222
- 23 Ruol A, Portale G, Zaninotto G , et al. Results of esophagectomy for esophageal cancer in elderly patients: age has little influence on outcome and survival. J Thorac Cardiovasc Surg 2007; 133 (5) 1186-1192
- 24 Heidecke CD, Weighardt H, Feith M , et al. Neoadjuvant treatment of esophageal cancer: immunosuppression following combined radiochemotherapy. Surgery 2002; 132 (3) 495-501
- 25 Kumagai K, Rouvelas I, Tsai JA , et al. Meta-analysis of postoperative morbidity and perioperative mortality in patients receiving neoadjuvant chemotherapy or chemoradiotherapy for resectable oesophageal and gastro-oesophageal junctional cancers. Br J Surg 2014; 101 (4) 321-338
- 26 Rudin A, Flisberg P, Johansson J, Walther B, Lundberg CJ. Thoracic epidural analgesia or intravenous morphine analgesia after thoracoabdominal esophagectomy: a prospective follow-up of 201 patients. J Cardiothorac Vasc Anesth 2005; 19 (3) 350-357
- 27 Pöpping DM, Elia N, Marret E, Remy C, Tramèr MR. Protective effects of epidural analgesia on pulmonary complications after abdominal and thoracic surgery: a meta-analysis. Arch Surg 2008; 143 (10) 990-999 , discussion 1000
- 28 Michelet P, D'Journo XB, Roch A , et al. Perioperative risk factors for anastomotic leakage after esophagectomy: influence of thoracic epidural analgesia. Chest 2005; 128 (5) 3461-3466
- 29 Lázár G, Kaszaki J, Abrahám S , et al. Thoracic epidural anesthesia improves the gastric microcirculation during experimental gastric tube formation. Surgery 2003; 134 (5) 799-805
- 30 Ng JM. Update on anesthetic management for esophagectomy. Curr Opin Anaesthesiol 2011; 24 (1) 37-43
- 31 Kita T, Mammoto T, Kishi Y. Fluid management and postoperative respiratory disturbances in patients with transthoracic esophagectomy for carcinoma. J Clin Anesth 2002; 14 (4) 252-256
- 32 Brandstrup B, Tønnesen H, Beier-Holgersen R , et al; Danish Study Group on Perioperative Fluid Therapy. Effects of intravenous fluid restriction on postoperative complications: comparison of two perioperative fluid regimens: a randomized assessor-blinded multicenter trial. Ann Surg 2003; 238 (5) 641-648
- 33 Neal JM, Wilcox RT, Allen HW, Low DE. Near-total esophagectomy: the influence of standardized multimodal management and intraoperative fluid restriction. Reg Anesth Pain Med 2003; 28 (4) 328-334
- 34 Wei S, Tian J, Song X, Chen Y. Association of perioperative fluid balance and adverse surgical outcomes in esophageal cancer and esophagogastric junction cancer. Ann Thorac Surg 2008; 86 (1) 266-272
- 35 Hiltebrand LB, Kimberger O, Arnberger M, Brandt S, Kurz A, Sigurdsson GH. Crystalloids versus colloids for goal-directed fluid therapy in major surgery. Crit Care 2009; 13 (2) R40
- 36 Kimberger O, Arnberger M, Brandt S , et al. Goal-directed colloid administration improves the microcirculation of healthy and perianastomotic colon. Anesthesiology 2009; 110 (3) 496-504
- 37 Marjanovic G, Villain C, Timme S , et al. Colloid vs. crystalloid infusions in gastrointestinal surgery and their different impact on the healing of intestinal anastomoses. Int J Colorectal Dis 2010; 25 (4) 491-498
- 38 Chappell D, Jacob M, Hofmann-Kiefer K, Conzen P, Rehm M. A rational approach to perioperative fluid management. Anesthesiology 2008; 109 (4) 723-740
- 39 Oshima K, Kunimoto F, Hinohara H , et al. Evaluation of respiratory status in patients after thoracic esophagectomy using PiCCO system. Ann Thorac Cardiovasc Surg 2008; 14 (5) 283-288
- 40 Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986; 1 (8476) 307-310
- 41 Theodorou D, Drimousis PG, Larentzakis A, Papalois A, Toutouzas KG, Katsaragakis S. The effects of vasopressors on perfusion of gastric graft after esophagectomy. An experimental study. J Gastrointest Surg 2008; 12 (9) 1497-1501
- 42 Al-Rawi OY, Pennefather SH, Page RD, Dave I, Russell GN. The effect of thoracic epidural bupivacaine and an intravenous adrenaline infusion on gastric tube blood flow during esophagectomy. Anesth Analg 2008; 106 (3) 884-887 table of contents
- 43 Klijn E, Niehof S, de Jonge J, Gommers D, Ince C, van Bommel J. The effect of perfusion pressure on gastric tissue blood flow in an experimental gastric tube model. Anesth Analg 2010; 110 (2) 541-546
- 44 Biere SS, van Berge Henegouwen MI, Maas KW , et al. Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial. Lancet 2012; 379 (9829) 1887-1892
- 45 Tsujimoto H, Ono S, Sugasawa H, Ichikura T, Yamamoto J, Hase K. Gastric tube reconstruction by laparoscopy-assisted surgery attenuates postoperative systemic inflammatory response after esophagectomy for esophageal cancer. World J Surg 2010; 34 (12) 2830-2836
- 46 Dunn DH, Johnson EM, Morphew JA, Dilworth HP, Krueger JL, Banerji N. Robot-assisted transhiatal esophagectomy: a 3-year single-center experience. Dis Esophagus 2013; 26 (2) 159-166
- 47 Buise M, Van Bommel J, Mehra M, Tilanus HW, Van Zundert A, Gommers D. Pulmonary morbidity following esophagectomy is decreased after introduction of a multimodal anesthetic regimen. Acta Anaesthesiol Belg 2008; 59 (4) 257-261
- 48 Derogar M, Orsini N, Sadr-Azodi O, Lagergren P. Influence of major postoperative complications on health-related quality of life among long-term survivors of esophageal cancer surgery. J Clin Oncol 2012; 30 (14) 1615-1619
- 49 Wormuth JK, Heitmiller RF. Esophageal conduit necrosis. Thorac Surg Clin 2006; 16 (1) 11-22
- 50 Biere SS, Maas KW, Cuesta MA, van der Peet DL. Cervical or thoracic anastomosis after esophagectomy for cancer: a systematic review and meta-analysis. Dig Surg 2011; 28 (1) 29-35
- 51 Kim RH, Takabe K. Methods of esophagogastric anastomoses following esophagectomy for cancer: a systematic review. J Surg Oncol 2010; 101 (6) 527-533
- 52 Veeramootoo D, Parameswaran R, Krishnadas R , et al. Classification and early recognition of gastric conduit failure after minimally invasive esophagectomy. Surg Endosc 2009; 23 (9) 2110-2116
- 53 Solomon DG, Sasaki CT, Salem RR. An evaluation of the routine use of contrast radiography as a screening test for cervical anastomotic integrity after esophagectomy. Am J Surg 2012; 203 (4) 467-471
- 54 Tirnaksiz MB, Deschamps C, Allen MS, Johnson DC, Pairolero PC. Effectiveness of screening aqueous contrast swallow in detecting clinically significant anastomotic leaks after esophagectomy. Eur Surg Res 2005; 37 (2) 123-128
- 55 Boone J, Rinkes IB, van Leeuwen M, van Hillegersberg R. Diagnostic value of routine aqueous contrast swallow examination after oesophagectomy for detecting leakage of the cervical oesophagogastric anastomosis. ANZ J Surg 2008; 78 (9) 784-790
- 56 Page RD, Asmat A, McShane J, Russell GN, Pennefather SH. Routine endoscopy to detect anastomotic leakage after esophagectomy. Ann Thorac Surg 2013; 95 (1) 292-298
- 57 Turkyilmaz A, Eroglu A, Aydin Y, Tekinbas C, Muharrem Erol M, Karaoglanoglu N. The management of esophagogastric anastomotic leak after esophagectomy for esophageal carcinoma. Dis Esophagus 2009; 22 (2) 119-126
- 58 Hu Z, Yin R, Fan X , et al. Treatment of intrathoracic anastomotic leak by nose fistula tube drainage after esophagectomy for cancer. Dis Esophagus 2011; 24 (2) 100-107
- 59 Freeman RK, Vyverberg A, Ascioti AJ. Esophageal stent placement for the treatment of acute intrathoracic anastomotic leak after esophagectomy. Ann Thorac Surg 2011; 92 (1) 204-208 , discussion 208
- 60 Toshniwal J, Zabielski M, Fry LC, Mönkemüller K. Combination of the “bear claw” (over-the-scope-clip system) and fully covered stent for the treatment of post-operative anastomotic leak. Endoscopy 2012; 44 ( Suppl 2 UCTN): E288-E289
- 61 Böhm G, Mossdorf A, Klink C , et al. Treatment algorithm for postoperative upper gastrointestinal fistulas and leaks using combined vicryl plug and fibrin glue. Endoscopy 2010; 42 (7) 599-602
- 62 Wedemeyer J, Brangewitz M, Kubicka S , et al. Management of major postsurgical gastroesophageal intrathoracic leaks with an endoscopic vacuum-assisted closure system. Gastrointest Endosc 2010; 71 (2) 382-386
- 63 Gubler C, Schneider PM, Bauerfeind P. Complex anastomotic leaks following esophageal resections: the new stent over sponge (SOS) approach. Dis Esophagus 2013; 26 (6) 598-602
- 64 D'Cunha J, Rueth NM, Groth SS, Maddaus MA, Andrade RS. Esophageal stents for anastomotic leaks and perforations. J Thorac Cardiovasc Surg 2011; 142 (1) 39-46.e1
- 65 van Boeckel PG, Sijbring A, Vleggaar FP, Siersema PD. Systematic review: temporary stent placement for benign rupture or anastomotic leak of the oesophagus. Aliment Pharmacol Ther 2011; 33 (12) 1292-1301
- 66 Gockel I, Kneist W, Keilmann A, Junginger T. Recurrent laryngeal nerve paralysis (RLNP) following esophagectomy for carcinoma. Eur J Surg Oncol 2005; 31 (3) 277-281
- 67 Wright CD, Zeitels SM. Recurrent laryngeal nerve injuries after esophagectomy. Thorac Surg Clin 2006; 16 (1) 23-33, v v
- 68 Rubin AD, Sataloff RT. Vocal fold paresis and paralysis. Otolaryngol Clin North Am 2007; 40 (5) 1109-1131 , viii–ix
- 69 Lerut TE, van Lanschot JJ. Chronic symptoms after subtotal or partial oesophagectomy: diagnosis and treatment. Best Pract Res Clin Gastroenterol 2004; 18 (5) 901-915
- 70 Schild HH, Strassburg CP, Welz A, Kalff J. Treatment options in patients with chylothorax. Dtsch Arztebl Int 2013; 110 (48) 819-826
- 71 Breaux JR, Marks C. Chylothorax causing reversible T-cell depletion. J Trauma 1988; 28 (5) 705-707
- 72 Skouras V, Kalomenidis I. Chylothorax: diagnostic approach. Curr Opin Pulm Med 2010; 16 (4) 387-393
- 73 Chalret du Rieu M, Baulieux J, Rode A, Mabrut JY. Management of postoperative chylothorax. J Vis Surg 2011; 148 (5) e346-e352
- 74 Boffa DJ, Sands MJ, Rice TW , et al. A critical evaluation of a percutaneous diagnostic and treatment strategy for chylothorax after thoracic surgery. Eur J Cardiothorac Surg 2008; 33 (3) 435-439
- 75 Hölscher AH, Fetzner UK, Bludau M, Leers J. Complications and management of complications in oesophageal surgery. Zentralbl Chir 2011; 136 (3) 213-223
- 76 Oezcelik A, DeMeester SR, Hindoyan K , et al. Circular stapled pyloroplasty: a fast and effective technique for pyloric disruption during esophagectomy with gastric pull-up. Dis Esophagus 2011; 24 (6) 423-429