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J Neurol Surg A Cent Eur Neurosurg 2015; 76(05): 341-347
DOI: 10.1055/s-0034-1543959
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Will an Asymptomatic Meningioma Grow or Not Grow? A Meta-analysis

Lingcheng Zeng
1   Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China
,
Pei Liang
2   Sensory Science Laboratory, School of Bioscience and Food Engineering, Changshu Institute of Technology, China
,
Jiantong Jiao
1   Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China
,
Jian Chen
1   Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China
,
Ting Lei
1   Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China
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Publikationsverlauf

06. Mai 2014

24. Oktober 2014

Publikationsdatum:
23. März 2015 (online)

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Abstract

Background The treatment strategy for patients with an asymptomatic meningioma is still controversial. Key to an optimal decision is a careful evaluation of the growth possibilities of the meningioma by taking the patient's clinicoradiologic factors into consideration. However, previous studies have disagreed about the risk factors relating to tumor growth.

Methods A comprehensive search of PubMed, Embase, and the ISI Web of Knowledge was performed. Using a meta-analysis with nine subsidiary studies including 777 patients, we analyzed the correlation of the growth pattern of meningioma with patient gender, tumor location, tumor calcification, magnetic resonance imaging (MRI) T2 signal intensity, and peritumoral brain edema.

Results The growth rate of meningioma was negatively correlated with tumor calcification (odds ratio [OR]: 0.23; 95% confidence interval (CI), 0.11–0.46; p < 0.001) but positively associated with MRI T2 signal intensity (OR: 2.75; 95% CI, 1.75–4.33; p < 0.001). No correlations were found between tumor growth and other factors such as gender (OR: 1.29; 95% CI, 0.84–1.99; p = 0.24), skull base location (OR: 0.80; 95% CI, 0.25–2.58; p = 0.70), and peritumoral brain edema (OR: 1.24; 95% CI, 0.29–5.27; p = 0.77).

Conclusions Two factors, tumor calcification and low MRI T2 signal intensity, indicate the possibility of a slow growth meningioma. In such cases of asymptomatic meningioma, a follow-up strategy can be preferentially considered.

Keywords

asymptomatic meningioma - natural history - meta-analysis