Evaluation of Partial Transection versus Synovial Debridement of the ACL as Novel Canine Models for Management of ACL Injuries

Chantelle C. Bozynski; Keiichi Kuroki; James P. Stannard; Patrick A. Smith; Aaron M. Stoker; Cristi R. Cook; James L. Cook

doi:10.1055/s-0035-1544975

The Journal of Knee Surgery, Inhaltsverzeichnis

J Knee Surg 2015; 28(05): 404-410
DOI: 10.1055/s-0035-1544975

Original Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Evaluation of Partial Transection versus Synovial Debridement of the ACL as Novel Canine Models for Management of ACL Injuries

Autor*innen

Chantelle C. Bozynski

¹Comparative Orthopaedic Laboratory, University of Missouri, Columbia, Missouri
Keiichi Kuroki

¹Comparative Orthopaedic Laboratory, University of Missouri, Columbia, Missouri
James P. Stannard

²Department of Orthopaedic Surgery, University of Missouri Hospital, Columbia, Missouri
Patrick A. Smith

³Department of Orthopaedic Surgery, Columbia Orthopaedic Group, Columbia, Missouri
Aaron M. Stoker

¹Comparative Orthopaedic Laboratory, University of Missouri, Columbia, Missouri
Cristi R. Cook

¹Comparative Orthopaedic Laboratory, University of Missouri, Columbia, Missouri
James L. Cook

¹Comparative Orthopaedic Laboratory, University of Missouri, Columbia, Missouri

Abstract

A major hurdle in investigating important clinical questions in knee ligament treatment is a lack of valid translational animal models. This study characterizes the effects of partial transection versus synovial debridement of the anterior (cranial) cruciate ligament (ACL) in dogs. A total of 27 adult purpose-bred research hounds underwent surgery and were assessed over the following 8 weeks. Dogs were randomized into the following three ACL status groups: sham control (n = 9), intact ACL with synovial debridement (exposed ACL) (n = 9), and partial transection of the ACL (partial tear ACL) (n = 9). Dogs in the exposed ACL group and partial tear ACL group had significantly (p < 0.05) more severe lameness, pain, effusion, reduced function, and reduced comfortable range of motion compared with controls, with the partial tear ACL group being most severely affected. More severe ACL and whole-joint pathology, and radiographic scores for osteoarthritis were present in the partial tear ACL group compared with exposed and/or sham control group. On the basis of these findings, biologic components of ACL injury (exposed ACL) played a role in whole-joint inflammation, but the clinical and pathological effects were more severe when both biologic and biomechanical components were present (i.e., partial tear ACL). These novel canine models were successfully developed to evaluate partial transection versus synovial debridement of the ACL and these models will be used to evaluate treatment options for acute management of ACL injuries.

Keywords

anterior cruciate ligament - osteoarthritis - canine - model

Volltext

Referenzen

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