Lignans from the Fruits of Melia toosendan and Their Agonistic Activities on Melatonin Receptor MT₁

Abstract

Investigation on the fruits of Melia toosendan afforded seven new lignans (1–7), along with seventeen known compounds (8–24). The structures of the new compounds, involving four neo-lignans (1–4), two sesquilignans (5–6), and a nor-lignan (7), were elucidated based on extensive spectroscopic analyses (high-resolution electrospray ionization mass spectra, ultraviolet, infrared, one-dimensional and two-dimensional nuclear magnetic resonance). Compound 24 exhibited activity on melatonin receptor type 1 with an agonistic rate of 57.77 % at 1.02 mM according to the assay on HEK293 cell lines in vitro.

Key words

Melia toosendan - Meliaceae - lignans - MT₁ receptor - agonistic activity

• References

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