Download PDF
Clin Colon Rectal Surg 2015; 28(02): 099-102
DOI: 10.1055/s-0035-1547336
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Behcet Colitis

Anne B. Chin
1   Department of Surgery, Medstar Georgetown University Hospital, Washington, District of Columbia
,
Anjali S. Kumar
2   Section of Colon and Rectal Surgery, Medstar Washington Hospital Center, Washington, District of Columbia
› Author Affiliations
Further Information

Publication History

Publication Date:
25 May 2015 (online)

Also available at
   Permissions and Reprints

Abstract

Behcet disease (BD) is a chronic, multisystem, inflammatory disease characterized by variable clinical manifestations involving systemic vasculitis of both the small and large blood vessels. The majority of BD patients present with recurrent oral ulcers in combination with other manifestations of the disease, including genital ulcers, skin lesions, arthritis, uveitis, thrombophlebitis, gastrointestinal or central nervous system involvement. Gastrointestinal BD occurs in 3 to 25% of the BD patients and shares many clinical characteristics with inflammatory bowel disease (IBD). Consequently, the differentiation between IBD and gastrointestinal manifestation of BD is very difficult. Intestinal BD should be considered in patients who present with abdominal pain, diarrhea, weight loss, and rectal bleeding who are susceptible or at a risk for intestinal BD.

Keywords

Behcet disease - colitis - inflammatory bowel diseases
 

  • References

  • 1 Moutsopoulos HM. Behcet's Syndrome. In: Longo DL FA, Kasper DL, Hauser SL, Jameson J, Loscalzo J, , ed. Harrison's Principles of Internal Medicine, 18e. New York, NY: McGraw-Hill; 2012. .
    Search in Google Scholar
  • 2 Grigg EL, Kane S, Katz S. Mimicry and deception in inflammatory bowel disease and intestinal Behçet disease. Gastroenterol Hepatol (NY) 2012; 8 (2) 103-112
    PubMedSearch in Google Scholar
  • 3 Sands BE. From symptom to diagnosis: clinical distinctions among various forms of intestinal inflammation. Gastroenterology 2004; 126 (6) 1518-1532
    CrossrefPubMedSearch in Google Scholar
  • 4 Yurdakul S, Tüzüner N, Yurdakul I, Hamuryudan V, Yazici H. Gastrointestinal involvement in Behçet's syndrome: a controlled study. Ann Rheum Dis 1996; 55 (3) 208-210
    CrossrefPubMedSearch in Google Scholar
  • 5 Koutroubakis IE. Spectrum of non-inflammatory bowel disease and non-infectious colitis. World J Gastroenterol 2008; 14 (48) 7277-7279
    CrossrefPubMedSearch in Google Scholar
  • 6 Yurdakul S, Yazici H. Behçet's syndrome. Best Pract Res Clin Rheumatol 2008; 22 (5) 793-809
    CrossrefPubMedSearch in Google Scholar
  • 7 Yazici H, Tüzün Y, Pazarli H , et al. Influence of age of onset and patient's sex on the prevalence and severity of manifestations of Behçet's syndrome. Ann Rheum Dis 1984; 43 (6) 783-789
    CrossrefPubMedSearch in Google Scholar
  • 8 Mizuki N, Inoko H, Ohno S. Pathogenic gene responsible for the predisposition of Behçet's disease. Int Rev Immunol 1997; 14 (1) 33-48
    CrossrefPubMedSearch in Google Scholar
  • 9 Oshima Y, Shimizu T, Yokohari R , et al. Clinical studies on Behçet's syndrome. Ann Rheum Dis 1963; 22 (1) 36-45
    CrossrefPubMedSearch in Google Scholar
  • 10 International Study Group for Behçet's Disease. Criteria for diagnosis of Behçet's disease. Lancet 1990; 335 (8697) 1078-1080
    PubMedSearch in Google Scholar
  • 11 Yazici H, Yazici Y. Criteria for Behçet's disease with reflections on all disease criteria. J Autoimmun 2014; 48-49: 104-107
    CrossrefPubMedSearch in Google Scholar
  • 12 Hatemi I, Hatemi G, Celik AF , et al. Frequency of pathergy phenomenon and other features of Behçet's syndrome among patients with inflammatory bowel disease. Clin Exp Rheumatol 2008; ; 26 (4, Suppl 50): S91-S95
    PubMedSearch in Google Scholar
  • 13 Shin SJ, Kim BC, Kim TI, Lee SK, Lee KH, Kim WH. Anti-alpha-enolase antibody as a serologic marker and its correlation with disease severity in intestinal Behçet's disease. Dig Dis Sci 2011; 56 (3) 812-818
    CrossrefPubMedSearch in Google Scholar
  • 14 Bayraktar Y, Ozaslan E, Van Thiel DH. Gastrointestinal manifestations of Behcet's disease. J Clin Gastroenterol 2000; 30 (2) 144-154
    CrossrefPubMedSearch in Google Scholar
  • 15 Kim JS, Lim SH, Choi IJ , et al. Prediction of the clinical course of Behçet's colitis according to macroscopic classification by colonoscopy. Endoscopy 2000; 32 (8) 635-640
    Thieme ConnectPubMedSearch in Google Scholar
  • 16 Kim ES, Chung WC, Lee KM , et al. A case of intestinal Behcet's disease similar to Crohn's colitis. J Korean Med Sci 2007; 22 (5) 918-922
    CrossrefPubMedSearch in Google Scholar
  • 17 Sayek I, Aran O, Uzunalimoglu B, Hersek E. Intestinal Behçet's disease: surgical experience in seven cases. Hepatogastroenterology 1991; 38 (1) 81-83
    PubMedSearch in Google Scholar
  • 18 Jung YS, Yoon JY, Lee JH , et al. Prognostic factors and long-term clinical outcomes for surgical patients with intestinal Behcet's disease. Inflamm Bowel Dis 2011; 17 (7) 1594-1602
    CrossrefPubMedSearch in Google Scholar
  • 19 Moon CM, Cheon JH, Shin JK , et al. Prediction of free bowel perforation in patients with intestinal Behçet's disease using clinical and colonoscopic findings. Dig Dis Sci 2010; 55 (10) 2904-2911
    CrossrefPubMedSearch in Google Scholar
  • 20 Sakane T, Takeno M, Suzuki N, Inaba G. Behçet's disease. N Engl J Med 1999; 341 (17) 1284-1291
    CrossrefPubMedSearch in Google Scholar