The Role of a Mitochondrial Progesterone Receptor (PR-M) in Progesterone Action

Thomas M. Price; Qunsheng Dai

doi:10.1055/s-0035-1552583

Seminars in Reproductive Medicine, Inhaltsverzeichnis

Semin Reprod Med 2015; 33(03): 185-194
DOI: 10.1055/s-0035-1552583

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

The Role of a Mitochondrial Progesterone Receptor (PR-M) in Progesterone Action

Thomas M. Price

¹Division of Reproductive Endocrinology and Fertility, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina

,

Qunsheng Dai

¹Division of Reproductive Endocrinology and Fertility, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina

› Institutsangaben

Abstract

Historically, progesterone functions to regulate gene expression via two nuclear progesterone receptors (PR-B and PR-A). Yet, actions of progesterone independent of gene regulation have been observed for decades. These are based on progesterone induced cellular events that occur too rapidly to involve gene transcription or in cells lacking active gene transcription such as mature spermatozoa. Understanding of these “nongenomic” effects has been slowed by the lack of identification of specific receptors. Previous discovery of a mitochondrial progesterone receptor, PR-M, has opened up the possibility of direct, ligand-dependent modulation of mitochondrial activity. In this article, we review the current knowledge of PR-M and speculate on possible physiologic and pathophysiologic actions.

Keywords

mitochondrial progesterone receptor - cellular respiration - mitochondrial membrane potential - thermogenesis

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References
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