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DOI: 10.1055/s-0035-1552670
Nichtpharmakologische Interventionen zur Prävention von Gewichtszunahme bei schizophrenen Patienten unter antipsychotischer Medikation
Systematische Übersichtsarbeit und MetaanalyseNon-Pharmacological Interventions for the Prevention of Weight Gain in Schizophrenic Patients Treated with Antipsychotic MedicationSystematic Review and Meta-AnalysisPublikationsverlauf
Publikationsdatum:
09. Juli 2015 (online)
![](https://www.thieme-connect.de/media/psychiat-praxis/201507/lookinside/thumbnails/617_10-1055-s-0035-1552670-1.jpg)
Zusammenfassung
Ziel: Systematische Übersicht über den aktuellen Forschungsstand zu nichtpharmakologischen Interventionen zur Prävention von Gewichtszunahme bei Patienten mit Schizophrenie unter atypischer antipsychotischer Medikation.
Methode: Systematische Literaturrecherche, Einschluss aller kontrollierten Studien.
Ergebnisse: Verhaltenstherapeutische Interventionen scheinen die Gewichtszunahme zu reduzieren, hinsichtlich der Wirksamkeit von Ernährungsberatung sind die Ergebnisse widersprüchlich.
Schlussfolgerung: Weitere methodisch hochwertige Studien werden benötigt.
Abstract
Objective: To evaluate the effect of non-pharmacological interventions to prevent anti-psychotic medication induced weight gain in patients with a first episode of schizophrenia.
Methods: We searched electronic databases Medline, Embase and PsychINFO and reference lists of articles. Controlled trials evaluating the beneficial effects of non-pharmacological interventions to prevent weight gain were eligible for inclusion. Two authors independently assessed the risk of bias of the studies and extracted data.
Results: 9 studies met the inclusion criteria. Evaluation of studies was carried out separately according to the different interventions. Six studies examined the effect of behavioral interventions. Two meta-analysis were conducted and found small effects on weight management in favor of the behavioral intervention. Three studies reported the effect of nutritional counselling yielding contradictory results .
Conclusions: There is currently no clear evidence which intervention is the best to prevent antipsychotic-induced weight gain in patients with first episode of schizophrenia. Further trials of high methodological quality are necessary.
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