PDF herunterladen
Klinische Neurophysiologie 2015; 46(02): 56-64
DOI: 10.1055/s-0035-1552683
Fort- und Weiterbildung
© Georg Thieme Verlag KG Stuttgart · New York

Botulinumtoxin-Therapie in der Neurologie: Indikationen, Technik und Ultraschallsteuerung

Botulinum Toxin Treatment in Neurology: Indications, Technique and Ultrasound-Guidance
U. Walter
1   Klinik und Poliklinik für Neurologie, Universitätsmedizin Rostock
,
D. Dressler
2   Sektion Bewegungsstörungen, Klinik für Neurologie und Klinische Neurophysiologie, Medizinische Hochschule Hannover
› Institutsangaben
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
30. Juni 2015 (online)

Auch verfügbar auf
  Lizenzen und Reprints

Lernziele

  • Grundkenntnisse des Muskel-Ultraschalls

  • Topografische Grundkenntnisse des Ultraschallbildes von Muskeln und Drüsen

  • Neurologische Anwendungsgebiete der Botulinumtoxin-Therapie

  • Einsatzgebiete der ultraschallgeführten Botulinumtoxin-Injektion

 

  • Literatur

  • 1 Dressler D. Clinical applications of botulinum toxin. Curr Opin Microbiol 2012; 15: 325-336
    CrossrefPubMedSuche in Google Scholar
  • 2 Jankovic D, Peng P, van Zundert A. Brief review: Piriformis syndrome: etiology, diagnosis, and management. Can J Anesth 2013; 60: 1003-1012
    CrossrefPubMedSuche in Google Scholar
  • 3 Torriani M, Gupta R, Donahue DM. Botulinum toxin injection in neurogenic thoracic outlet syndrome: results and experience using a ultrasound-guided approach. Skeletal Radiol 2010; 39: 973-980
    CrossrefPubMedSuche in Google Scholar
  • 4 Su PH, Wang TG, Wang YC. Ultrasound-guided injection of botulinum toxin in a patient with omohyoid muscle syndrome: a case report. J Clin Ultrasound 2013; 41: 373-376
    CrossrefPubMedSuche in Google Scholar
  • 5 Aurora SK, Winner P, Freeman MC et al. OnabotulinumtoxinA for treatment of chronic migraine: pooled analyses of the 56-week PREEMPT clinical program. Headache 2011; 51: 1358-1373
    CrossrefPubMedSuche in Google Scholar
  • 6 Henzel MK, Munin MC, Niyonkuru C et al. Comparison of surface and ultrasound localization to identify forearm flexor muscles for botulinum toxin injections. PM R 2010; 2: 642-646
    CrossrefPubMedSuche in Google Scholar
  • 7 Chin TY, Nattrass GR, Selber P et al. Accuracy of intramuscular injection of botulinum toxin A in juvenile cerebral palsy: a comparison between manual needle placement and placement guided by electrical stimulation. J Pediatr Orthop 2005; 25: 286-291
    CrossrefPubMedSuche in Google Scholar
  • 8 Picelli A, Bonetti P, Fontana C et al. Accuracy of botulinum toxin type A injection into the gastrocnemius muscle of adults with spastic equinus: manual needle placement and electrical stimulation guidance compared using ultrasonography. J Rehabil Med 2012; 44: 450-452
    CrossrefPubMedSuche in Google Scholar
  • 9 Schnitzler A, Roche N, Denormandie P et al. Manual needle placement: accuracy of botulinum toxin A injections. Muscle Nerve 2012; 46: 531-534
    CrossrefPubMedSuche in Google Scholar
  • 10 Jankovic J. Needle EMG guidance for injection of botulinum toxin. Needle EMG guidance is rarely required. Muscle Nerve 2001; 24: 1568-1570
    CrossrefPubMedSuche in Google Scholar
  • 11 Mall V, Heinen F, Siebel A et al. Treatment of adductor spasticity with BTX-A in children with CP: a randomized, double-blind, placebo-controlled study. Dev Med Child Neurol 2006; 48: 10-13
    PubMedSuche in Google Scholar
  • 12 Barbano RL. Needle EMG guidance for injection of botulinum toxin. Needle EMG guidance is useful. Muscle Nerve 2001; 24: 1567-1568
    CrossrefPubMedSuche in Google Scholar
  • 13 Childers MK, Wilson DJ, Gnatz SM et al. Botulinum toxin type A use in piriformis muscle syndrome: a pilot study. Am J Phys Med Rehabil 2002; 81: 751-759
    CrossrefPubMedSuche in Google Scholar
  • 14 Jordan SE, Ahn SS, Gelabert HA. Combining ultrasonography and electromyography for botulinum chemodenervation treatment of thoracic outlet syndrome: comparison with fluoroscopy and electromyography guidance. Pain Physician 2007; 10: 541-546
    PubMedSuche in Google Scholar
  • 15 Glass GA, Ku S, Ostrem JL et al. Fluoroscopic, EMG-guided injection of botulinum toxin into the longus colli for the treatment of anterocollis. Parkinsonism Relat Disord 2009; 15: 610-613
    CrossrefPubMedSuche in Google Scholar
  • 16 Garcia Ruiz PJ, Perez Higueras A, Quiñones D et al. Posterior CT guided approach for botulinum toxin injection into spinal psoas. J Neurol 2003; 250: 617-618
    CrossrefPubMedSuche in Google Scholar
  • 17 Stenner A, Reichel G, Hermann W. Successful treatment of piriformis syndrome with botulinum toxin A [abstract]. J Neurol 2006; 253 (Suppl. 02) II/110
    PubMedSuche in Google Scholar
  • 18 Reichel G. Cervical dystonia: A new phenomenological classification for botulinum toxin therapy. Basal Ganglia 2011; 1: 5-12
    CrossrefPubMedSuche in Google Scholar
  • 19 Mashayekh A, Christo PJ, Yousem DM et al. CT-guided injection of the anterior and middle scalene muscles: technique and complications. AJNR Am J Neuroradiol 2011; 32: 495-500
    CrossrefPubMedSuche in Google Scholar
  • 20 Mezaki T, Matsumoto S, Sakamoto T et al. Cervical echomyography in cervical dystonia and its application to the monitoring for muscle afferent block (MAB). Rinsho Shinkeigaku 2000; 40: 689-693
    PubMedSuche in Google Scholar
  • 21 Berweck S, Feldkamp A, Francke A et al. Sonography-guided injection of botulinum toxin A in children with cerebral palsy. Neuropediatrics 2002; 33: 221-223
    Thieme ConnectPubMedSuche in Google Scholar
  • 22 Boon AJ, Oney-Marlow TM, Murthy NS et al. Accuracy of electromyography needle placement in cadavers: non-guided vs. ultrasound guided. Muscle Nerve 2011; 44: 45-49
    CrossrefPubMedSuche in Google Scholar
  • 23 Peetrons P. Ultrasound of muscles. Eur Radiol 2002; 12: 35-43
    CrossrefPubMedSuche in Google Scholar
  • 24 Schmidt WA, Backhaus M, Sattler H et al. Imaging techniques in rheumatology: sonography in rheumatoid arthritis. Z Rheumatol 2003; 62: 23-33
    CrossrefPubMedSuche in Google Scholar
  • 25 Reimers CD, Fleckenstein JL, Witt TN et al. Muscular ultrasound in idiopathic inflammatory myopathies of adults. J Neurol Sci 1993; 116: 82-92
    CrossrefPubMedSuche in Google Scholar
  • 26 Reimers CD, Schlotter B, Eicke BM et al. Calf enlargement in neuromuscular diseases: a quantitative ultrasound study in 350 patients and review of the literature. J Neurol Sci 1996; 143: 46-56
    CrossrefPubMedSuche in Google Scholar
  • 27 Mayans D, Cartwright MS, Walker FO. Neuromuscular ultrasonography: quantifying muscle and nerve measurements. Phys Med Rehabil Clin N Am 2012; 23: 133-148
    CrossrefPubMedSuche in Google Scholar
  • 28 To EW, Ahuja AT, Ho WS et al. A prospective study of the effect of botulinum toxin A on masseteric muscle hypertrophy with ultrasonographic and electromyographic measurement. Br J Plast Surg 2001; 54: 197-200
    CrossrefPubMedSuche in Google Scholar
  • 29 Stokes M, Hides J, Elliott J et al. Rehabilitative ultrasound imaging of the posterior paraspinal muscles. J Orthop Sports Phys Ther 2007; 37: 581-595
    CrossrefPubMedSuche in Google Scholar
  • 30 English C, Fisher L, Thoirs K. Reliability of real-time ultrasound for measuring skeletal muscle size in human limbs in vivo: a systematic review. Clin Rehabil 2012; 26: 934-944
    CrossrefPubMedSuche in Google Scholar
  • 31 Alfen NV, Gilhuis HJ, Keijzers JP et al. Quantitative facial muscle ultrasound: feasibility and reproducibility. Muscle Nerve 2013; 48: 375-380
    CrossrefPubMedSuche in Google Scholar
  • 32 Katz P, Hartl DM, Guerre A. Clinical ultrasound of the salivary glands. Otolaryngol Clin North Am 2009; 42: 973-1000
    Suche in Google Scholar
  • 33 Tacik P, Dressler D. Ultraschallgestützte Botulinumtoxin-Injektionen in der Neurologie. Klin Neurophysiol 2013; 44: 1-9
    Thieme ConnectPubMedSuche in Google Scholar
  • 34 Kopf H, Mostbeck GH, Loizides A et al. Ultrasound-guided interventions at peripheral nerves: diagnostic and therapeutic indications. Ultraschall Med 2011; 32: 440-456
    Thieme ConnectPubMedSuche in Google Scholar
  • 35 Walter U, Dressler D. Ultrasound-guided botulinum toxin injections in neurology: technique, indications and future perspectives. Expert Rev Neurother 2014; 14: 923-936
    CrossrefPubMedSuche in Google Scholar
  • 36 Hobson-Webb LD, Boon AJ. Reporting the results of diagnostic neuromuscular ultrasound: an educational report. Muscle Nerve 2013; 47: 608-610
    CrossrefPubMedSuche in Google Scholar
  • 37 Schramm A, Bäumer T, Fietzek U et al. Relevance of sonography for botulinum toxin treatment of cervical dystonia: an expert statement. J Neural Transm 2014;
    PubMedSuche in Google Scholar
  • 38 Gervasio A, D’Orta G, Mujahed I et al. Sonographic anatomy of the neck: The suprahyoid region. J Ultrasound 2011; 14: 130-135
    CrossrefPubMedSuche in Google Scholar
  • 39 Chaukar DA, Sayed SI, Shetty NS et al. Ultrasound-guided botulinum toxin injection: A simple in-office technique to improve tracheoesophageal speech in postlaryngectomy patients. Head Neck 2013; 35: E122-125
    CrossrefPubMedSuche in Google Scholar
  • 40 Blitzer A. Spasmodic dysphonia and botulinum toxin: experience from the largest treatment series. Eur J Neurol 2010; 17 (Suppl. 01) 28-30
    CrossrefPubMedSuche in Google Scholar
  • 41 Reichel G. Therapieleitfaden Spastik – Dystonien. Bremen: UNI-MED; 2012: 160
    Suche in Google Scholar
  • 42 Gervasio A, Mujahed I, Biasio A et al. Ultrasound anatomy of the neck: The infrahyoid region. J Ultrasound 2010; 13: 85-89
    CrossrefPubMedSuche in Google Scholar
  • 43 Heinen F, Desloovere K, Schroeder AS et al. The updated European Consensus 2009 on the use of Botulinum toxin for children with cerebral palsy. Eur J Paediatr Neurol 2010; 14: 45-66
    CrossrefPubMedSuche in Google Scholar
  • 44 Westhoff B, Seller K, Wild A et al. Ultrasound-guided botulinum toxin injection technique for the iliopsoas muscle. Dev Med Child Neurol 2003; 45: 829-832
    PubMedSuche in Google Scholar
  • 45 Sconfienza LM, Perrone N, Lacelli F et al. Ultrasound-guided injection of botulinum toxin A in the treatment of iliopsoas spasticity. J Ultrasound 2008; 11: 113-117
    CrossrefPubMedSuche in Google Scholar
  • 46 Lee IH, Yoon YC, Sung DH et al. Initial experience with imaging-guided intramuscular botulinum toxin injection in patients with idiopathic cervical dystonia. AJR Am J Roentgenol 2009; 192: 996-1001
    CrossrefPubMedSuche in Google Scholar
  • 47 Javanshir K, Mohseni-Bandpei MA, Rezasoltani A et al. Ultrasonography of longus colli muscle: A reliability study on healthy subjects and patients with chronic neck pain. J Bodyw Mov Ther 2011; 15: 50-56
    CrossrefPubMedSuche in Google Scholar
  • 48 Fujimoto H, Mezaki T, Yokoe M et al. Sonographic guidance provides a low-risk approach to the longus colli muscle. Mov Disord 2012; 27: 928-929
    CrossrefPubMedSuche in Google Scholar
  • 49 Hong JS, Sathe GG, Niyonkuru C et al. Elimination of dysphagia using ultrasound guidance for botulinum toxin injections in cervical dystonia. Muscle Nerve 2012; 46: 535-539
    CrossrefPubMedSuche in Google Scholar
  • 50 Picelli A, Lobba D, Midiri A et al. Botulinum toxin injection into the forearm muscles for wrist and fingers spastic overactivity in adults with chronic stroke: a randomized controlled trial comparing three injection techniques. Clin Rehabil 2014; 28: 232-242
    CrossrefPubMedSuche in Google Scholar
  • 51 Santamato A, Micello MF, Panza F et al. Can botulinum toxin type A injection technique influence the clinical outcome of patients with post-stroke upper limb spasticity? A randomized controlled trial comparing manual needle placement and ultrasound-guided injection techniques. J Neurol Sci 2014; 347: 39-43
    CrossrefPubMedSuche in Google Scholar
  • 52 Picelli A, Tamburin S, Bonetti P et al. Botulinum toxin type A injection into the gastrocnemius muscle for spastic equinus in adults with stroke: a randomized controlled trial comparing manual needle placement, electrical stimulation and ultrasonography-guided injection techniques. Am J Phys Med Rehabil 2012; 91: 957-964
    CrossrefPubMedSuche in Google Scholar
  • 53 Lim EC, Quek AM, Seet RC. Accurate targeting of botulinum toxin injections: how to and why. Parkinsonism Relat Disord 2011; 17 (Suppl. 01) S34-39
    CrossrefPubMedSuche in Google Scholar
  • 54 Dogu O, Apaydin D, Sevim S et al. Ultrasound-guided versus 'blind' intraparotid injections of botulinum toxin-A for the treatment of sialorrhoea in patients with Parkinson’s disease. Clin Neurol Neurosurg 2004; 106: 93-96
    CrossrefPubMedSuche in Google Scholar
  • 55 Porta M, Gamba M, Bertacchi G et al. Treatment of sialorrhoea with ultrasound guided botulinum toxin type A injection in patients with neurological disorders. J Neurol Neurosurg Psychiatry 2001; 70: 538-540
    CrossrefPubMedSuche in Google Scholar
  • 56 Turk-Gonzales M, Odderson IR. Quantitative reduction of saliva production with botulinum toxin type B injection into the salivary glands. Neurorehabil Neural Repair 2005; 19: 58-61
    CrossrefPubMedSuche in Google Scholar
  • 57 Breheret R, Bizon A, Jeufroy C et al. Ultrasound-guided botulinum toxin injections for treatment of drooling. Eur Ann Otorhinolaryngol Head Neck Dis 2011; 128: 224-229
    CrossrefPubMedSuche in Google Scholar
  • 58 Jeung IS, Lee S, Kim HS et al. Effect of botulinum toxin a injection into the salivary glands for sialorrhea in children with neurologic disorders. Ann Rehabil Med 2012; 36: 340-346
    CrossrefPubMedSuche in Google Scholar
  • 59 Chan KH, Liang C, Wilson P et al. Long-term safety and efficacy data on botulinum toxin type A: an injection for sialorrhea. JAMA Otolaryngol Head Neck Surg 2013; 139: 134-138
    CrossrefPubMedSuche in Google Scholar
  • 60 Giovagnorio F, Pace F, Giorgi A. Sonography of lacrimal glands in Sjögren syndrome. J Ultrasound Med 2000; 19: 505-509
    PubMedSuche in Google Scholar