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DOI: 10.1055/s-0035-1553350
Age Dependency of Myocardial Triglyceride Content: A 3T High-Field 1H-MR Spectroscopy Study
Untersuchung der Altersabhängigkeit myokardialer Triglycerid-Konzentrationen mit 1H-MR-Spektroskopie bei 3 TPublikationsverlauf
23. Oktober 2014
07. Juni 2015
Publikationsdatum:
31. Juli 2015 (online)
![](https://www.thieme-connect.de/media/roefo/201511/lookinside/thumbnails/roefo-2376_10-1055-s-0035-1553350-1.jpg)
Abstract
Purpose: The role of myocardial triglyceride (mTG) content in the aging human heart is not entirely understood. The aim of this study was to measure concentrations of mTG content from healthy volunteers and to determine the association between age, mTG content and systolic heart function. Furthermore, the technical stability of the 1H-magnetic resonance spectroscopy (1H-MRS) and the reliability of peak evaluation at 3 T were evaluated.
Materials and Methods: The total study population of 47 healthy volunteers was divided into 4 age classes, according to the age of the subjects (1st cohort 20 – 29 years (yrs.), n = 20; 2nd cohort 30 – 39 yrs., n = 10; 3rd cohort 40 – 49 yrs., n = 9; 4th cohort 50 – 60 yrs., n = 8). Cardiac MRI and double triggered 1H-MRS of the myocardium were consecutively performed using a 3 T scanner. Each participant underwent spectroscopic measurements twice in the same investigation.
Results: mTG content increases with age. The correlation of age and mTG is minimal (r = 0.48; p < 0.001). The following age-averaged mTG content values expressed as % of mTG signal compared to the water signal were determined for each cohort: 1st cohort 0.25 % (± 0.17); 2nd cohort 0.48 % (± 0.30); 3rd cohort 0.48 % (± 0.18); 4th cohort 0.77 % (± 0.70). There was no significant correlation (r = 0.04; p = n.s.) between LV mass and mTG content in healthy volunteers. Within our cohorts, no effects of age or mTG content on systolic heart function were seen (r = – 0.01; p = n.s.). The intraclass correlation coefficient of spectroscopic measurements was high (r = 0.965; p < 0.001).
Conclusion: Myocardial TG content increases with age. The normal age-dependent concentration ranges of myocardial lipid metabolites reported in this study may be helpful for the correction of acquired 1H-MRS data in patients when evaluating metabolic and cardiovascular diseases in future magnetic resonance spectroscopy studies.
Key Points:
• 1H-MRS enables noninvasive myocardial lipid determination
• Double triggered 1H-MRS of the heart at 3 T is a technically stable and reliable method
• Myocardial triglyceride content increases with age
• Myocardial triglyceride content is independent of LV mass and systolic function
Citation Format:
• Petritsch B, Gassenmaier T, Kunz AS et al. Age Dependency of Myocardial Triglyceride Content: A 3T High-Field 1H-MR Spectroscopy Study. Fortschr Röntgenstr 2015; 187: 1016 – 1021
Zusammenfassung
Ziel: Die Rolle myokardialer Triglyceride (mTG) im alternden menschlichen Herz wurde bis dato noch nicht ausführlich untersucht. Das Ziel dieser Studie war die Konzentration von mTG an gesunden Probanden zu messen und Zusammenhänge zwischen Alter, mTG-Konzentration und systolischer Herzfunktion aufzuzeigen. Des Weiteren sollte die technische Zuverlässigkeit der Protonen-MR-Spektroskopie (1H-MRS) am Herzen bei einer Feldstärke von 3 T untersucht werden.
Material und Methoden: Insgesamt 47 gesunde Probanden wurden entsprechend ihres jeweiligen Alters in 4 Kohorten unterteilt (1. Kohorte 20 – 29 Jahre, n = 20; 2. Kohorte 30 – 39 Jahre, n = 10; 3. Kohorte 40 – 49 Jahre, n = 9; 4. Kohorte 50 – 51 Jahre, n = 8). Kardiale MRT und doppelt getriggerte 1H-MRS des Myokards wurden unmittelbar nacheinander an einem 3 T Gerät durchgeführt. Von jedem Teilnehmer wurden in einem Untersuchungsgang zwei spektroskopische Messungen akquiriert.
Ergebnisse: Der mTG Gehalt korreliert mit dem Lebensalter (r = 0,48; p < 0,001). Folgende altersgemittelte mTG Werte (angegeben als mTG/Wasser-Resonanz-Verhältnis in Prozent) wurden ermittelt: 1 Kohorte 0,25 % (± 0,17); 2 Kohorte 0,48 % (± 0,30); 3 Kohorte 0,48 % (± 0,18); 4 Kohorte 0,77 % (± 0,70). Die mTG-Konzentration in Gesunden ist unabhängig von der LV-Masse (r = 0,04; p = n.s.) und der systolischen Herzfunktion (r = – 0,01; p = n.s.) Die technische Zuverlässigkeit der 1H-MRS des Herzens bzw. die Reproduzierbarkeit der mTG Werte waren hoch (r = 0,965; p < 0,001).
Schlussfolgerung: Die myokardiale TG-Konzentration bei Gesunden nimmt mit dem Alter zu. Die ermittelten mTG-Konzentrationen aus dieser Studie könnten als Orientierungswerte für Normalkollektive in zukünftigen 1H-MRS Studien herangezogen werden.
Kernaussagen:
• 1H-MRS ermöglicht die nicht invasive myokardiale Lipid Bestimmung
• Die doppelt getriggerte 1H-MRS des Herzens bei 3 T ist eine technisch zuverlässig Methode
• Die myokardiale Triglyerid-Konzentration steigt mit dem Lebensalter
• Die myokardiale Triglycerid-Konzentration ist unabhängig von der LV Masse und LV Funktion
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