Pineal Melatonin in a Sub-chronic Tryptophan Depletion Female Rat Model of Treatment-resistant Depression

M. Franklin; N. Hlavacova; S. Babic; I. Bermudez; D. Jezova

doi:10.1055/s-0035-1554711

Pharmacopsychiatry, Table of Contents

Pharmacopsychiatry 2015; 48(04/05): 181-183
DOI: 10.1055/s-0035-1554711

Letter

Pineal Melatonin in a Sub-chronic Tryptophan Depletion Female Rat Model of Treatment-resistant Depression

M. Franklin

¹School of Life Sciences, Oxford Brookes University, Oxford OX3 0BP, UK

,

N. Hlavacova

²Institute of Experimental Endocrinology, Laboratory of Pharmacological Neuroendocrinology, Slovak Academy of Sciences, Bratislava, Slovakia

,

S. Babic

²Institute of Experimental Endocrinology, Laboratory of Pharmacological Neuroendocrinology, Slovak Academy of Sciences, Bratislava, Slovakia

,

I. Bermudez

¹School of Life Sciences, Oxford Brookes University, Oxford OX3 0BP, UK

,

D. Jezova

²Institute of Experimental Endocrinology, Laboratory of Pharmacological Neuroendocrinology, Slovak Academy of Sciences, Bratislava, Slovakia

› Author Affiliations

Abstract

Key words

animal models - melatonin - sleep disturbances - cortisol - depression

Full Text

References

References
1 Murck H, Schüssler P, Steiger A. Renin-angiotensin-aldosterone system: the forgotten stress hormone system: relationship to depression and sleep. Pharmacopsychiatry 2012; 45: 83-95
2 Franklin M, Hafizi 1 S, Reed A et al. Effect of sub-chronic treatment with Jarsin (extract of St John’s wort, Hypericum perforatum) at two dose levels on evening salivary melatonin and cortisol concentrations in healthy male volunteers. Pharmacopsychiatry 2006; 39: 13-15
3 Pandi-Perunal SR, Moscovitch A, Srinivasan V et al. Bidirectional communication between sleep and circadian rhythms and its implications for depression: lessons from agomelatine. Progress in Neurobiology 2009; 88: 264-271
4 Solarewicz JZ, Angoa-Perez M, Kuhn DM et al. The sleep-wake cycle and motor activity, but not temperature, are disrupted over the light-dark cycle in mice genetically depleted of serotonin. American Journal Physiology Regulatory Integrative and Comparative Physiology 2015; 30891: R10-R17
5 Villela D, Atherino VF, de Sá Lima L et al. Modulation of pineal melatonin synthesis by glutamate involves paracrine interactions between pinealocytes and astrocytes through NF-κB activation. BioMed International 2013; ID618432
6 Kaur C, Sivakumar V, Ling EA. Expression of N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) GluR2/3 receptors in the developing rat pineal gland. Journal of Pineal Research 2005; 39: 294-301
7 Franklin M, Clement EM, Campling G et al. Effect of venlafaxine on pineal melatonin and noradrenaline in the male rat. Journal Psychopharmacology 1998; 12: 371-274
8 Zimmermann RC, McDougle CJ, Schumacher M et al. Effects of acute tryptophan depletion on nocturnal melatonin secretion in humans. J Clinical Endocrinology Metabolism 1993; 76: 1160-1164
9 Franklin M, Bermudez I, Murck H et al. Sub-chronic dietary tryptophan depletion – An animal model of depression with improved face and good construct validity. Journal of Psychiatric Research 2012; 46: 239-247
10 Franklin M, Bermudez I, Hlavacova N et al. Aldosterone increases earlier than corticosterone in new animal models of depression: Is this an early marker?. Journal of Psychiatric Research 2012; 46: 1394-1397
11 Franklin M, Hlavacova Babic S. et al. Aldosterone signals the onset of depressive behaviour in female rat model of depression along with SSRI-resistance. Neuroendocrinology in press
12 Hlavacova N, Wes PD, Ondrejcakova M et al. Subchronic treatment with aldosterone induces depression-like behaviours and gene expression changes relevant to major depressive disorder. Int J Neuropsychopharmacol 2012; 15: 247-265