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Semin Hear 2015; 36(03): 111-121
DOI: 10.1055/s-0035-1555115
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

The Impact of Age on Cognition

Daniel L. Murman
1   Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, Nebraska
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Publication Date:
09 July 2015 (online)

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Abstract

This article reviews the cognitive changes that occur with normal aging, the structural and functional correlates of these cognitive changes, and the prevalence and cognitive effects of age-associated diseases. Understanding these age-related changes in cognition is important given our growing elderly population and the importance of cognition in maintaining functional independence and effective communication with others. The most important changes in cognition with normal aging are declines in performance on cognitive tasks that require one to quickly process or transform information to make a decision, including measures of speed of processing, working memory, and executive cognitive function. Cumulative knowledge and experiential skills are well maintained into advanced age. Structural and function changes in the brain correlate with these age-related cognitive changes, including alterations in neuronal structure without neuronal death, loss of synapses, and dysfunction of neuronal networks. Age-related diseases accelerate the rate of neuronal dysfunction, neuronal loss, and cognitive decline, with many persons developing cognitive impairments severe enough to impair their everyday functional abilities. There is emerging evidence that healthy lifestyles may decrease the rate of cognitive decline seen with aging and help delay the onset of cognitive symptoms in the setting of age-associated diseases.

Keywords

Cognition - aging - neurodegeneration
 

  • References

  • 1 Vincent GK, Velkoff VA, Bureau USC. The next four decades: the older population in the United States: 2010 to 2050. Washington, DC: U.S. Dept. of Commerce, Economics and Statistics Administration, U.S. Census Bureau; 2010. Available at: http://purl.access.gpo.gov/GPO/LPS126596 . Accessed on June 3, 2015
  • 2 Alzheimer's A ; Alzheimer's Association. 2014 Alzheimer's disease facts and figures. Alzheimers Dement 2014; 10 (2) e47-e92
    CrossrefPubMedSearch in Google Scholar
  • 3 Harada CN, Natelson Love MC, Triebel KL. Normal cognitive aging. Clin Geriatr Med 2013; 29 (4) 737-752
    CrossrefPubMedSearch in Google Scholar
  • 4 Salthouse TA. Selective review of cognitive aging. J Int Neuropsychol Soc 2010; 16 (5) 754-760
    CrossrefPubMedSearch in Google Scholar
  • 5 Levy R. Aging-associated cognitive decline. Working Party of the International Psychogeriatric Association in collaboration with the World Health Organization. Int Psychogeriatr 1994; 6 (1) 63-68
    CrossrefPubMedSearch in Google Scholar
  • 6 Lezak MD, Howieson DB, Bigler ED, Tranel D. Neuropsychological Assessment. 5th ed. New York, NY: Oxford University Press; 2012
    Search in Google Scholar
  • 7 Salthouse T. Consequences of age-related cognitive declines. Annu Rev Psychol 2012; 63: 201-226
    CrossrefPubMedSearch in Google Scholar
  • 8 Sommers MS. Speech perception in older adults: the importance of speech-specific cognitive abilities. J Am Geriatr Soc 1997; 45 (5) 633-637
    CrossrefPubMedSearch in Google Scholar
  • 9 Wong PC, Ettlinger M, Sheppard JP, Gunasekera GM, Dhar S. Neuroanatomical characteristics and speech perception in noise in older adults. Ear Hear 2010; 31 (4) 471-479
    CrossrefPubMedSearch in Google Scholar
  • 10 Critchley M. And all the daughters of musick shall be brought low. Language function in the elderly. Arch Neurol 1984; 41 (11) 1135-1139
    CrossrefPubMedSearch in Google Scholar
  • 11 Raz N, Gunning FM, Head D , et al. Selective aging of the human cerebral cortex observed in vivo: differential vulnerability of the prefrontal gray matter. Cereb Cortex 1997; 7 (3) 268-282
    CrossrefPubMedSearch in Google Scholar
  • 12 Salat DH, Kaye JA, Janowsky JS. Prefrontal gray and white matter volumes in healthy aging and Alzheimer disease. Arch Neurol 1999; 56 (3) 338-344
    CrossrefPubMedSearch in Google Scholar
  • 13 Madden DJ, Spaniol J, Costello MC , et al. Cerebral white matter integrity mediates adult age differences in cognitive performance. J Cogn Neurosci 2009; 21 (2) 289-302
    CrossrefPubMedSearch in Google Scholar
  • 14 Dennis EL, Thompson PM. Functional brain connectivity using fMRI in aging and Alzheimer's disease. Neuropsychol Rev 2014; 24 (1) 49-62
    CrossrefPubMedSearch in Google Scholar
  • 15 Pannese E. Morphological changes in nerve cells during normal aging. Brain Struct Funct 2011; 216 (2) 85-89
    CrossrefPubMedSearch in Google Scholar
  • 16 Morrison JH, Hof PR. Life and death of neurons in the aging brain. Science 1997; 278 (5337) 412-419
    CrossrefPubMedSearch in Google Scholar
  • 17 Terry RD, Masliah E, Salmon DP , et al. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol 1991; 30 (4) 572-580
    CrossrefPubMedSearch in Google Scholar
  • 18 Masliah E, Mallory M, Hansen L, DeTeresa R, Terry RD. Quantitative synaptic alterations in the human neocortex during normal aging. Neurology 1993; 43 (1) 192-197
    CrossrefPubMedSearch in Google Scholar
  • 19 Terry RD, Katzman R. Life span and synapses: will there be a primary senile dementia?. Neurobiol Aging 2001; 22 (3) 347-348 , discussion 353–354
    CrossrefPubMedSearch in Google Scholar
  • 20 Stern Y. What is cognitive reserve? Theory and research application of the reserve concept. J Int Neuropsychol Soc 2002; 8 (3) 448-460
    CrossrefPubMedSearch in Google Scholar
  • 21 Richards M, Deary IJ. A life course approach to cognitive reserve: a model for cognitive aging and development?. Ann Neurol 2005; 58 (4) 617-622
    CrossrefPubMedSearch in Google Scholar
  • 22 Morrison JH, Baxter MG. The ageing cortical synapse: hallmarks and implications for cognitive decline. Nat Rev Neurosci 2012; 13 (4) 240-250
    PubMedSearch in Google Scholar
  • 23 Brier MR, Thomas JB, Snyder AZ , et al. Unrecognized preclinical Alzheimer disease confounds rs-fcMRI studies of normal aging. Neurology 2014; 83 (18) 1613-1619
    CrossrefPubMedSearch in Google Scholar
  • 24 Steffener J, Brickman AM, Habeck CG, Salthouse TA, Stern Y. Cerebral blood flow and gray matter volume covariance patterns of cognition in aging. Hum Brain Mapp 2013; 34 (12) 3267-3279
    CrossrefPubMedSearch in Google Scholar
  • 25 Maillet D, Rajah MN. Association between prefrontal activity and volume change in prefrontal and medial temporal lobes in aging and dementia: a review. Ageing Res Rev 2013; 12 (2) 479-489
    CrossrefPubMedSearch in Google Scholar
  • 26 Sonnen JA, Larson EB, Crane PK , et al. Pathological correlates of dementia in a longitudinal, population-based sample of aging. Ann Neurol 2007; 62 (4) 406-413
    CrossrefPubMedSearch in Google Scholar
  • 27 Schneider JA, Arvanitakis Z, Bang W, Bennett DA. Mixed brain pathologies account for most dementia cases in community-dwelling older persons. Neurology 2007; 69 (24) 2197-2204
    CrossrefPubMedSearch in Google Scholar
  • 28 Boyle PA, Yu L, Wilson RS, Schneider JA, Bennett DA. Relation of neuropathology with cognitive decline among older persons without dementia. Front Aging Neurosci 2013; 5: 50
    PubMedSearch in Google Scholar
  • 29 Boyle PA, Wilson RS, Yu L , et al. Much of late life cognitive decline is not due to common neurodegenerative pathologies. Ann Neurol 2013; 74 (3) 478-489
    CrossrefPubMedSearch in Google Scholar
  • 30 Evans DA, Funkenstein HH, Albert MS , et al. Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported. JAMA 1989; 262 (18) 2551-2556
    CrossrefPubMedSearch in Google Scholar
  • 31 Fjell AM, McEvoy L, Holland D, Dale AM, Walhovd KB ; Alzheimer's Disease Neuroimaging Initiative. What is normal in normal aging? Effects of aging, amyloid and Alzheimer's disease on the cerebral cortex and the hippocampus. Prog Neurobiol 2014; 117: 20-40
    CrossrefPubMedSearch in Google Scholar
  • 32 Morris JC, Price JL. Pathologic correlates of nondemented aging, mild cognitive impairment, and early-stage Alzheimer's disease. J Mol Neurosci 2001; 17 (2) 101-118
    CrossrefPubMedSearch in Google Scholar
  • 33 Gauthier S, Reisberg B, Zaudig M , et al; International Psychogeriatric Association Expert Conference on mild cognitive impairment. Mild cognitive impairment. Lancet 2006; 367 (9518) 1262-1270
    CrossrefPubMedSearch in Google Scholar
  • 34 Bateman RJ, Xiong C, Benzinger TL , et al; Dominantly Inherited Alzheimer Network. Clinical and biomarker changes in dominantly inherited Alzheimer's disease. N Engl J Med 2012; 367 (9) 795-804
    CrossrefPubMedSearch in Google Scholar
  • 35 Sperling RA, Aisen PS, Beckett LA , et al. Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 2011; 7 (3) 280-292
    CrossrefPubMedSearch in Google Scholar
  • 36 Dubois B, Feldman HH, Jacova C , et al. Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria. Lancet Neurol 2014; 13 (6) 614-629
    CrossrefPubMedSearch in Google Scholar
  • 37 Roe CM, Fagan AM, Grant EA , et al. Amyloid imaging and CSF biomarkers in predicting cognitive impairment up to 7.5 years later. Neurology 2013; 80 (19) 1784-1791
    CrossrefPubMedSearch in Google Scholar
  • 38 Jack Jr CR, Wiste HJ, Weigand SD , et al. Age-specific population frequencies of cerebral β-amyloidosis and neurodegeneration among people with normal cognitive function aged 50–89 years: a cross-sectional study. Lancet Neurol 2014; 13 (10) 997-1005
    CrossrefPubMedSearch in Google Scholar
  • 39 Fotuhi M, Do D, Jack C. Modifiable factors that alter the size of the hippocampus with ageing. Nat Rev Neurol 2012; 8 (4) 189-202
    PubMedSearch in Google Scholar
  • 40 Bano D, Agostini M, Melino G, Nicotera P. Ageing, neuronal connectivity and brain disorders: an unsolved ripple effect. Mol Neurobiol 2011; 43 (2) 124-130
    CrossrefPubMedSearch in Google Scholar
  • 41 Angevaren M, Aufdemkampe G, Verhaar HJ, Aleman A, Vanhees L. Physical activity and enhanced fitness to improve cognitive function in older people without known cognitive impairment. Cochrane Database Syst Rev 2008; (2) CD005381
    PubMedSearch in Google Scholar
  • 42 Carvalho A, Rea IM, Parimon T, Cusack BJ. Physical activity and cognitive function in individuals over 60 years of age: a systematic review. Clin Interv Aging 2014; 9: 661-682
    PubMedSearch in Google Scholar
  • 43 Willis SL, Tennstedt SL, Marsiske M , et al; ACTIVE Study Group. Long-term effects of cognitive training on everyday functional outcomes in older adults. JAMA 2006; 296 (23) 2805-2814
    CrossrefPubMedSearch in Google Scholar
  • 44 Okonkwo OC, Schultz SA, Oh JM , et al. Physical activity attenuates age-related biomarker alterations in preclinical AD. Neurology 2014; 83 (19) 1753-1760
    CrossrefPubMedSearch in Google Scholar
  • 45 Woods B, Aguirre E, Spector AE, Orrell M. Cognitive stimulation to improve cognitive functioning in people with dementia. Cochrane Database Syst Rev 2012; 2: CD005562
    PubMedSearch in Google Scholar