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DOI: 10.1055/s-0035-1555153
Pseudotumor Cerebri Syndrome and Renal Diseases in the Pediatric Population
Publikationsverlauf
27. Oktober 2014
06. Januar 2015
Publikationsdatum:
13. Juli 2015 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00029030/201501/lookinside/thumbnails/10-1055-s-0035-1555153_1511-1.jpg)
Abstract
Pseudotumor cerebri syndrome (PTCS) is defined as a syndrome of markedly elevated intracranial pressure, with no evidence of intracranial mass, inflammation or obstruction on brain imaging. Headache, visual disturbances (e.g., diplopia, visual loss), and papilledema are the most common presenting features. The mechanism(s) underlying PTCS is still unknown. Numerous medical illnesses and medications have been associated with the risk of PTCS, and a range of renal disorders (e.g., renal transplantation, nephrotic syndrome, inherited tubulopathies, acute or chronic kidney insufficiency) can predispose to developing this raised intracranial pressure syndrome. Fluid and electrolyte balance in renal epithelial cells are regulated by a complex interaction of metabolic and/or hormonal factors. In this context, we also discuss recent studies that suggest that renal epithelial cells share many of the same features as the choroid plexus epithelial cells, which are involved in the regulation of cerebrospinal fluid dynamics.
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References
- 1 Friedman DI, Liu GT, Digre KB. Revised diagnostic criteria for the pseudotumor cerebri syndrome in adults and children. Neurology 2013; 81 (13) 1159-1165
- 2 Rangwala LM, Liu GT. Pediatric idiopathic intracranial hypertension. Surv Ophthalmol 2007; 52 (6) 597-617
- 3 Soiberman U, Stolovitch C, Balcer LJ, Regenbogen M, Constantini S, Kesler A. Idiopathic intracranial hypertension in children: visual outcome and risk of recurrence. Childs Nerv Syst 2011; 27 (11) 1913-1918
- 4 Salpietro V, Polizzi A, Bertè LF , et al. Idiopathic intracranial hypertension: a unifying neuroendocrine hypothesis through the adrenal-brain axis. Neuroendocrinol Lett 2012; 33 (6) 569-573
- 5 Salpietro V, Chimenz R, Arrigo T, Ruggieri M. Pediatric idiopathic intracranial hypertension and extreme childhood obesity: a role for weight gain. J Pediatr 2013; 162 (5) 1084
- 6 Chang D, Nagamoto G, Smith WE. Benign intracranial hypertension and chronic renal failure. Cleve Clin J Med 1992; 59 (4) 419-422
- 7 Dobrowolsky W. Amourosis uraemia in folge von schnervenoedem. Klin Monatsbl Augenheilkd 1881; 19: 121-123 (in German)
- 8 Barnett M, Sinha MD, Morrison D, Lim M. Intracranial hypertension presenting with severe visual failure, without concurrent headache, in a child with nephrotic syndrome. BMC Pediatr 2013; 13: 167
- 9 Francis PJ, Haywood S, Rigden S, Calver DM, Clark G. Benign intracranial hypertension in children following renal transplantation. Pediatr Nephrol 2003; 18 (12) 1265-1269
- 10 Chamberlain CE, Fitzgibbon E, Wassermann EM , et al. Idiopathic intracranial hypertension following kidney transplantation: a case report and review of the literature. Pediatr Transplant 2005; 9 (4) 545-550
- 11 Tugal O, Jacobson R, Berezin S , et al. Recurrent benign intracranial hypertension due to iron deficiency anemia. Case report and review of the literature. Am J Pediatr Hematol Oncol 1994; 16 (3) 266-270
- 12 Perna AF, Ingrosso D, Molino D , et al. Hyperhomocysteinemia and protein damage in chronic renal failure and kidney transplant pediatric patients—Italian initiative on uremic hyperhomocysteinemia (IIUH). J Nephrol 2003; 16 (4) 516-521
- 13 Biousse V, Ameri A, Bousser MG. Isolated intracranial hypertension as the only sign of cerebral venous thrombosis. Neurology 1999; 53 (7) 1537-1542
- 14 Pasini A, Aceto G, Ammenti A , et al; NefroKid Study Group. Best practice guidelines for idiopathic nephrotic syndrome: recommendations versus reality. Pediatr Nephrol 2015; 30 (1) 91-101
- 15 Fede C, Conti G, Chimenz R, Ricca M. N-acetyl-beta-D-glucosaminidase and beta2-microglobulin: prognostic markers in idiopathic nephrotic syndrome. J Nephrol 1999; 12 (1) 51-55
- 16 Ammenti A, Müller-Wiefel DE, Schärer K, Vecsei P. Mineralocorticoids in the nephrotic syndrome of children. Clin Nephrol 1980; 14 (5) 238-245
- 17 Yang GF, Schoepf UJ, Zhu H, Lu GM, Gray III JC, Zhang LJ. Thromboembolic complications in nephrotic syndrome: imaging spectrum. Acta Radiol 2012; 53 (10) 1186-1194
- 18 Salpietro V, Ruggieri M. Pseudotumor cerebri pathophysiology: the likely role of aldosterone. Headache 2014; 54 (7) 1229
- 19 Khan MU, Khalid H, Salpietro V, Weber KT. Idiopathic intracranial hypertension associated with either primary or secondary aldosteronism. Am J Med Sci 2013; 346 (3) 194-198
- 20 Vidal E, Edefonti A, Murer L , et al; Italian Registry of Paediatric Chronic Dialysis. Peritoneal dialysis in infants: the experience of the Italian Registry of Paediatric Chronic Dialysis. Nephrol Dial Transplant 2012; 27 (1) 388-395
- 21 Ghosh S, Sarkar K, Mukhopadhyay S, Bhaduri G. Idiopathic intracranial hypertension in a child after hemodialysis. Pediatr Neurol 2008; 39 (4) 272-275
- 22 Belson A, Alcorn DM, Yorgin PD, Fisher PG, Sarwal M. Visual loss caused by pseudotumor cerebri in an infant on peritoneal dialysis. Pediatr Nephrol 2001; 16 (3) 216-218
- 23 Korzets A, Gafter U, Floru S, Chagnac A, Zevin D. Deteriorating renal function with acetazolamide in a renal transplant patient with pseudotumor cerebri. Am J Kidney Dis 1993; 21 (3) 322-4
- 24 Salpietro V, Ruggieri M, Sancetta F , et al. New insights on the relationship between pseudotumor cerebri and secondary hyperaldosteronism in children. J Hypertens 2012; 30 (3) 629-630
- 25 Konomi H, Imai M, Nihei K, Kamoshita S, Tada H. Indomethacin causing pseudotumor cerebri in Bartter's syndrome. N Engl J Med 1978; 298 (15) 855
- 26 Larizza D, Colombo A, Lorini R, Severi F. Ketoprofen causing pseudotumor cerebri in Bartter's syndrome. N Engl J Med 1979; 300 (14) 796
- 27 Godefroid N, Riveira-Munoz E, Saint-Martin C, Nassogne MC, Dahan K, Devuyst O. A novel splicing mutation in SLC12A3 associated with Gitelman syndrome and idiopathic intracranial hypertension. Am J Kidney Dis 2006; 48 (5) e73-e79
- 28 Seyberth HW, Schlingmann KP. Bartter- and Gitelman-like syndromes: salt-losing tubulopathies with loop or DCT defects. Pediatr Nephrol 2011; 26 (10) 1789-1802
- 29 Salpietro V, Polizzi A, Di Rosa G , et al. Adrenal disorders and the paediatric brain: pathophysiological considerations and clinical implications. Int J Endocrinol 2014; 2014: 282489
- 30 Andrews LE, Liu GT, Ko MW. Idiopathic intracranial hypertension and obesity. Horm Res Paediatr 2014; 81 (4) 217-225
- 31 Salpietro V, Mankad K, Kinali M , et al. Pediatric idiopathic intracranial hypertension and the underlying endocrine-metabolic dysfunction: a pilot study. J Pediatr Endocrinol Metab 2014; 27 (1–2) 107-115
- 32 Chirico V, Lacquaniti A, Salpietro V , et al. High-mobility group box 1 (HMGB1) in childhood: from bench to bedside. Eur J Pediatr 2014; 173 (9) 1123-1136
- 33 Chirico V, Cannavò S, Lacquaniti A , et al. Prolactin in obese children: a bridge between inflammation and metabolic-endocrine dysfunction. Clin Endocrinol (Oxf) 2013; 79 (4) 537-544
- 34 Chirico V, Ferraù V, Loddo I , et al. LMNA gene mutation as a model of cardiometabolic dysfunction: from genetic analysis to treatment response. Diabetes Metab 2014; 40 (3) 224-228
- 35 Arrigo T, Chirico V, Salpietro V , et al. High-mobility group protein B1: a new biomarker of metabolic syndrome in obese children. Eur J Endocrinol 2013; 168 (4) 631-638
- 36 Sheldon CA, Kwon YJ, Liu GT, McCormack SE. An integrated mechanism of pediatric pseudotumor cerebri syndrome: evidence of bioenergetic and hormonal regulation of cerebrospinal fluid dynamics. Pediatr Res 2015; 77 (2) 282-289
- 37 Boedtkjer E, Praetorius J, Füchtbauer EM, Aalkjaer C. Antibody-independent localization of the electroneutral Na+-HCO3- cotransporter NBCn1 (slc4a7) in mice. Am J Physiol Cell Physiol 2008; 294 (2) C591-C603
- 38 Keep RF, Smith DE. Choroid plexus transport: gene deletion studies. Fluids Barriers CNS 2011; 8 (1) 26
- 39 Johanson CE, Duncan III JA, Klinge PM, Brinker T, Stopa EG, Silverberg GD. Multiplicity of cerebrospinal fluid functions: new challenges in health and disease. Cerebrospinal Fluid Res 2008; 5: 10