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Exp Clin Endocrinol Diabetes 2015; 123(08): 446-450
DOI: 10.1055/s-0035-1555877
Article
© Georg Thieme Verlag KG Stuttgart · New York

The Association between Macroprolactin Levels and Vitamin D Status in Premenopausal Women with Macroprolactinemia: A Pilot Study

R. Krysiak
1   Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland
,
B. Kowalska
1   Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland
2   Department of Endocrinology, Provincial Hospital, Opole, Poland
,
W. Szkróbka
1   Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland
,
B. Okopień
1   Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland
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Publikationsdatum:
15. Juli 2015 (online)

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Abstract

Background: Macroprolactinemia is a frequent cause of misdiagnosis and mismanagement of patients with elevated prolactin levels. Its pathogenesis and clinical significance are still controversial.

Methods: The aim of this study was to investigate the relationship between elevated macroprolactin content and vitamin D status. The study population included 20 premenopausal women with isolated macroprolactinemia, 10 of whom were later treated with vitamin D (2 000 IU daily). Serum prolactin, macroprolactin, 25-hydroxyvitamin D and PTH levels were assessed at baseline and after 4 months of treatment.

Results: Compared with the control age- and weight-women with normal prolactin levels (n=11), patients with macroprolactinemia were characterized by lower levels of 25-hydroxyvitamin D and slightly higher levels of PTH. Vitamin D administered to patients with macroprolactinemia increased 25-hydroxyvitamin, reduced total prolactin and macroprolactin, as well tended to reduce PTH. The effect of vitamin D on total prolactin and macroprolactin correlated with their baseline values and baseline 25-hydroxyvitamin D levels.

Conclusions: The results of our study suggest the association between vitamin D status and elevated macroprolactin levels in premenopausal women.

Key words

vitamin D - hyperprolactinemia - macroprolactinemia - polyethylene glycol assay
 

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