Planta Med 2015; 81 - PT26
DOI: 10.1055/s-0035-1556404

Diverse oligopeptides isolated from aquatic microbial consortia

L Pan 1, H Chai 1, AD Kinghorn 1, GT Carter 2
  • 1Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
  • 2Biosortia Pharmaceuticals, 565 Metro Place South, Suite 300 Dublin, Ohio 43017, and National Oceanic and Atmospheric Administration (NOAA), Charleston, South Carolina 29412, USA

Bioassay-guided purification has conducted on fractions prepared from uniquely harvested biomass of aquatic microalgae using HT-29 human colon cancer cell line, and has led to the isolation of a number of oligopeptides, with the most representative sub-types being anabaenopepetins, oscillapeptins and aeruginosins. The structures of the isolated compounds were identified on the basis of spectroscopic data interpretation. A LC-MS dereplication procedure was employed to facilitate the minor cytotoxic agents isolation.