The Emerging Role of Chronic Low-Grade Inflammation in the Pathophysiology of Polycystic Ovary Syndrome

Soulmaz Shorakae; Helena Teede; Barbora de Courten; Gavin Lambert; Jacqueline Boyle; Lisa J. Moran

doi:10.1055/s-0035-1556568

Seminars in Reproductive Medicine, Table of Contents

Semin Reprod Med 2015; 33(04): 257-269
DOI: 10.1055/s-0035-1556568

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

The Emerging Role of Chronic Low-Grade Inflammation in the Pathophysiology of Polycystic Ovary Syndrome

Authors

Soulmaz Shorakae

¹Monash Centre for Health Research and Implementation, Monash University, Melbourne, Australia
Helena Teede

¹Monash Centre for Health Research and Implementation, Monash University, Melbourne, Australia

²Diabetes and Vascular Medicine Unit, Monash Health, Clayton, Australia
Barbora de Courten

¹Monash Centre for Health Research and Implementation, Monash University, Melbourne, Australia

²Diabetes and Vascular Medicine Unit, Monash Health, Clayton, Australia
Gavin Lambert

³Human Neurotransmitters Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Australia

⁴Department of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia
Jacqueline Boyle

¹Monash Centre for Health Research and Implementation, Monash University, Melbourne, Australia
Lisa J. Moran

¹Monash Centre for Health Research and Implementation, Monash University, Melbourne, Australia

⁵The Robinson Research Institute, School of Paediatrics and Reproductive Health, The University of Adelaide, The Robinson Research Institute, Australia

Abstract

Polycystic ovary syndrome (PCOS) has become increasingly common over recent years and is associated with reproductive features as well as cardiometabolic risk factors, including visceral obesity, dyslipidemia and impaired glucose homeostasis, and potentially cardiovascular disease. Emerging evidence suggests that these long-term metabolic effects are linked to a low-grade chronic inflammatory state with the triad of hyperinsulinemia, hyperandrogenism, and low-grade inflammation acting together in a vicious cycle in the pathophysiology of PCOS. Dysregulation of the sympathetic nervous system may also act as an important component, potentially creating a tetrad in the pathophysiology of PCOS. The aim of this review is to examine the role of chronic inflammation and the sympathetic nervous system in the development of obesity and PCOS and review potential therapeutic options to alleviate low-grade inflammation in this setting.

Keywords

polycystic ovary syndrome - obesity - chronic low-grade inflammation - sympathetic nervous system

Full Text

References

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