Differences in Eccentricity Index and Systolic–Diastolic Ratio in Extremely Low-Birth-Weight Infants with Bronchopulmonary Dysplasia at Risk of Pulmonary Hypertension

A. W. McCrary; J. R. Malowitz; C. P. Hornick; K. D. Hill; C. M. Cotten; G. H. Tatum; P. C. Barker

doi:10.1055/s-0035-1556757

American Journal of Perinatology, Inhaltsverzeichnis

Am J Perinatol 2016; 33(01): 057-062
DOI: 10.1055/s-0035-1556757

Original Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Differences in Eccentricity Index and Systolic–Diastolic Ratio in Extremely Low-Birth-Weight Infants with Bronchopulmonary Dysplasia at Risk of Pulmonary Hypertension

A. W. McCrary

¹Department of Pediatrics, Duke University Hospital, Durham, North Carolina

,

J. R. Malowitz

²Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Duke University Hospital, Durham, North Carolina

,

C. P. Hornick

¹Department of Pediatrics, Duke University Hospital, Durham, North Carolina

,

K. D. Hill

³Division of Pediatric Cardiology, Department of Pediatrics, Duke University Hospital, Durham, North Carolina

,

C. M. Cotten

²Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Duke University Hospital, Durham, North Carolina

,

G. H. Tatum

³Division of Pediatric Cardiology, Department of Pediatrics, Duke University Hospital, Durham, North Carolina

,

P. C. Barker

³Division of Pediatric Cardiology, Department of Pediatrics, Duke University Hospital, Durham, North Carolina

› Institutsangaben

Abstract

Objective To compare the left ventricular eccentricity index (EI) and tricuspid valve systolic–diastolic (SD) ratio in infants at risk of bronchopulmonary dysplasia (BPD) and pulmonary hypertension (PH).

Study Design Review of echocardiograms performed on infants born at ≤ 28 weeks' postmenstrual age, categorized into the following three cohorts: BPD and PH (n = 13); BPD only (n = 16); and controls (n = 59). EI was measured from a parasternal short axis 2D image. The SD ratio was measured from the continuous wave Doppler tracing. Groups were compared using Kruskal–Wallis and Wilcoxon rank sum tests.

Result EI and SD ratios were successfully measured in all infants. There were no differences between controls and BPD cohort. In contrast, the BPD and PH cohort had increased systolic EI (1.46 vs. 1.00–1.01), diastolic EI (1.47 vs. 1.00), and SD ratio (1.12 vs. 0.97–1.00) compared with controls and BPD only cohort (p ≤ 0.01 for all).

Conclusion The EI and SD ratio may be useful as a screening tool for PH in this population.

Keywords

bronchopulmonary dysplasia - pulmonary hypertension - extremely low birth weight infants - eccentricity index - echocardiogram

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