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J Pediatr Infect Dis 2008; 03(02): 141-144
DOI: 10.1055/s-0035-1556972
Case Report
Georg Thieme Verlag KG Stuttgart – New York

Congenital rubella and hyperthyroidism: A case report

Georgia Gioula
a   B' Laboratory of Microbiology Virus Unit, School of Medicine, Aristotle University of Thessaloniki, Greece
,
Ioanna Evdoridou
b   Department of Neonatology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
,
Dimitrios Chatzidimitriou
a   B' Laboratory of Microbiology Virus Unit, School of Medicine, Aristotle University of Thessaloniki, Greece
,
Styliani Petridou
b   Department of Neonatology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
,
Angeliki Melidou
a   B' Laboratory of Microbiology Virus Unit, School of Medicine, Aristotle University of Thessaloniki, Greece
,
Vasiliki Drossou-Agakidou
b   Department of Neonatology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
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Publication History

13 July 2007

25 October 2007

Publication Date:
28 July 2015 (online)

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Abstract

A premature female infant with intrauterine growth restriction, microcephaly, hepatosplenomegaly and cholestasis developed hyperthyroidism on the fifth day of life. The mother had also developed hyperthyroidism during pregnancy. Real-time polymerase chain reaction was positive for rubella virus in samples from both mother (blood) and neonate (blood, nasopharyngeal swabs, urine). Immunoglobulin M antibodies for rubella virus were not found while immunoglobulin G antibodies were detected in mother's and neonate's serum. This case suggests the potential for a causal link between rubella and hyperthyroidism.

Keywords

Rubella - congenital - hyperthyroidism