Techniques and Approaches to Genetic Analyses in Nephrological Disorders

Laurel K. Willig

doi:10.1055/s-0035-1557108

Journal of Pediatric Genetics, Inhaltsverzeichnis

J Pediatr Genet 2016; 05(01): 002-014
DOI: 10.1055/s-0035-1557108

Review Article

Georg Thieme Verlag KG Stuttgart · New York

Techniques and Approaches to Genetic Analyses in Nephrological Disorders

Autor*innen

Laurel K. Willig

¹Center for Pediatric Genomic Medicine, Kansas City, Missouri, United States

²Division of Nephrology, Children's Mercy Hospital, Kansas City, Missouri, United States

³Department of Pediatrics, University of Missouri-Kansas City, Kansas City, Missouri, United States

Abstract

Inherited renal disease is a leading cause of morbidity and mortality in pediatric nephrology. High throughput advancements in genomics have led to greater understanding of the biologic underpinnings of these diseases. However, the underlying genetic changes explain only part of the molecular biology that contributes to disease manifestation and progression. Other omics technologies will provide a more complete picture of these cellular processes. This review discusses these omics technologies in the context of pediatric renal disease.

Keywords

next generation sequencing - nephrology - proteomics - genomics - metabolomics - epigenomics - transcriptomics

Volltext

Referenzen

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