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Journal of Pediatric Neurology 2004; 02(04): 225-229
DOI: 10.1055/s-0035-1557224
Case Report
Georg Thieme Verlag KG Stuttgart – New York

Macrophagic myofasciitis in a 3-month-old child[*]

Mehar C. Sharma
1   Department of Neuropathology, Johannes Gutenberg-University Mainz, Germany
,
Anibal Prentice
2   The Neurospinal Hospital, Dubai, United Arab Emirates
,
Peter F. Schmidt
3   Institute of Medical Physics and Biophysics, Wilhelms-University, Münster, Germany
,
Naresh Sharma
4   Department of Pediatrics, Welcare Hospital, Dubai, United Arab Emirates
,
Hans H. Goebel
1   Department of Neuropathology, Johannes Gutenberg-University Mainz, Germany
› Author Affiliations
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Further Information

Publication History

13 February 2004

04 May 2004

Publication Date:
29 July 2015 (online)

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Abstract

Macrophagic myofasciitis (MMF) is a rare inflammatory myopathy which occurs after injection of aluminium-containing vaccines against hepatitis B virus (HBV), hepatitis A virus, and tetanus toxoid. Most of the cases reported are from France and are adult patients. We report a rare case of MMF in a 3-month-old male child of Indian origin. He was immunized for HBV at birth after which he developed generalized hypotonia, and central nervous system and peripheral nervous system manifestations at 1 month of age. Muscle biopsy showed typical features of MMF and aluminium could be detected in the muscle biopsy macrophages by ultrastructural examination and LAMMA technique. Our case is the youngest case of MMF and one of few from Asia. (J Pediatr Neurol 2004; 2(4): 225–229).

Keywords

macrophagic myofasciitis - inflammatory myopathy - vaccine - aluminium - child

* This paper was presented at the Winter Meeting of the French Neuropathological Society, Paris, 2003.