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DOI: 10.1055/s-0035-1557234
An open clinical trial of risperidone in children with seizures and hyperactivity
Verantwortlicher Herausgeber dieser Rubrik:
Publikationsverlauf
31. März 2004
15. August 2004
Publikationsdatum:
29. Juli 2015 (online)
Abstract
Children with seizures may also have behavioral problems including hyperactivity. The management of hyperactivity in these cases is complicated by the fact that pharmacotherapeutic interventions may worsen the seizures. In this study 10 children with epilepsy and attention deficit hyperactivity disorder were treated with risperidone in an open label fashion. The dose was titrated up from 0.5 mg to a maximum of 3 mg per day based on clinical efficacy and tolerability. Clinical improvement was noted in all the 10 patients. Tiredness was reported by one patient, and drowsiness by another, but none experienced extra pyramidal side effects. Furthermore, there were no untoward effects on the frequency or intensity of the seizures. Our findings suggest that risperidone in combination with anticonvulsant medication is safe and effective in treating children with seizures and hyperactivity. Controlled studies are needed to determine long-term efficacy and safety of this drug in this special population.