Download PDF
Journal of Pediatric Neurology 2008; 06(03): 273-276
DOI: 10.1055/s-0035-1557458
Case Report
Georg Thieme Verlag KG Stuttgart – New York

Clinical features of a case with trisomy 10q and monosomy 3p resulting from a maternal balanced translocation

Frouzandeh Mahjoubi
a   Department of Clinical Genetics, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran
b   Tehran Medical Genetics Laboratory, Tehran, Iran
,
Mohammad Taghi Akbari
b   Tehran Medical Genetics Laboratory, Tehran, Iran
c   Department of Medical Genetics, Tarbiat Modaress University, Tehran, Iran
,
Gholamreza Babamohammadi
b   Tehran Medical Genetics Laboratory, Tehran, Iran
› Author Affiliations
Subject Editor:
Further Information

Publication History

17 December 2007

28 February 2008

Publication Date:
30 July 2015 (online)

Also available at
  PDF Download  Permissions and Reprints

Abstract

Here we describe clinical and cytogenetic data on 2-year-old female child with partial trisomy for the distal part of the long arm of chromosome 10 (10q22–>qter) and a concomitant monosomy 3(p25–>pter) as a result of a maternal balanced reciprocal translocation. Her karyotype was ascertained as 46,XX,der(3)t(3;10)(p25;q22). The father had normal karyotype. The mother had an apparently balanced translocation involving chromosome 3 and 10 [46,XX,t(3;10)(p25;q22)]. This is the second reported case of partial trisomy 10q and partial trisomy 3p. Clinical features of this case and a few published cases will be reviewed briefly.

Keywords

Trisomy 10q - monosomy 3p