Int J Angiol 2015; 24(03): 198-204
DOI: 10.1055/s-0035-1558644
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Intravascular Near-Infrared Spectroscopy: A Possible Tool for Optimizing the Management of Carotid Artery Disease

Martin Horváth
1   Department of Cardiology, Charles University in Prague, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic
,
Petr Hájek
1   Department of Cardiology, Charles University in Prague, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic
,
Cyril Štěchovský
1   Department of Cardiology, Charles University in Prague, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic
,
Jakub Honěk
1   Department of Cardiology, Charles University in Prague, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic
,
Josef Veselka
1   Department of Cardiology, Charles University in Prague, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic
› Author Affiliations
Further Information

Publication History

Publication Date:
06 August 2015 (online)

Abstract

Stroke is the second most common cause of morbidity and mortality in the Western nations. It is estimated that approximately one-fifth of all strokes or transient ischemic attacks are caused by carotid artery disease. Thus, treatment of carotid artery disease as a mean of stroke prevention is extremely important. Since the introduction of carotid endarterectomy, debate has persisted over the treatment strategy for carotid artery disease. Current recommendations have many potential flaws because they are often based on older trials performed before the introduction of modern pharmacotherapy and are mostly based on the angiographic degree of stenosis, without an emphasis on the pathophysiology of the disease. Most carotid events are caused by rupture or distal embolization of the content of an unstable atherosclerotic plaque with a large lipid pool. Thus, it is plausible that the information regarding the composition of the atherosclerotic plaque could play an important role in deciding on a treatment strategy. In this review article, we provide information about near-infrared spectroscopy, a new invasive imaging modality, which seems to be capable of providing such information.

Note

The authors declare that they have no commercial, proprietary, or financial interests in any products or companies described in this article.


 
  • References

  • 1 Brott TG, Halperin JL, Abbara S, Bacharach JM, Barr JD, Bush RL, Cates CU, Creager MA, Fowler SB, Friday G, Hertzberg VS, McIff EB, Moore WS, Panagos PD, Riles TS, Rosenwasser RH, Taylor AJ ; American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines; American Stroke Assocation; American Association of Neuroscience Nurses; American Association of Neurological Surgeons; American College of Radiology; American Society of Neuroradiology; Congress of Neurolgocial Surgeons; Society of Atherosclerosis Imaging and Prevention; Society for Cardiovascular Angiography and Interventions; Society of Interventional Radiology; Society of NeuroInterventional Surgery; Society for Vascular Medicine; Society for Vascular Surgery; American Academy of Neurology and Society of Cardiovascular Computed Tomography. 2011 ASA/ACCF/AHA/AANN/AANS/ACR/ASNR/CNS/SAIP/SCAI/SIR/SNIS/SVM/SVS guideline on the management of patients with extracranial carotid and vertebral artery disease. Stroke 2011; 42 (8) e464-540
  • 2 Tendera M, Aboyans V, Bartelink ML , et al; European Stroke Organisation; ESC Committee for Practice Guidelines. ESC Guidelines on the diagnosis and treatment of peripheral artery diseases: Document covering atherosclerotic disease of extracranial carotid and vertebral, mesenteric, renal, upper and lower extremity arteries: the Task Force on the Diagnosis and Treatment of Peripheral Artery Diseases of the European Society of Cardiology (ESC). Eur Heart J 2011; 32 (22) 2851-2906
  • 3 Donnan GA, Fisher M, Macleod M, Davis SM. Stroke. Lancet 2008; 371 (9624) 1612-1623
  • 4 Sacco RL, Kargman DE, Gu Q, Zamanillo MC. Race-ethnicity and determinants of intracranial atherosclerotic cerebral infarction. The Northern Manhattan Stroke Study. Stroke 1995; 26 (1) 14-20
  • 5 Barnett HJ, Gunton RW, Eliasziw M , et al. Causes and severity of ischemic stroke in patients with internal carotid artery stenosis. JAMA 2000; 283 (11) 1429-1436
  • 6 Inzitari D, Eliasziw M, Gates P , et al. The causes and risk of stroke in patients with asymptomatic internal-carotid-artery stenosis. North American Symptomatic Carotid Endarterectomy Trial Collaborators. N Engl J Med 2000; 342 (23) 1693-1700
  • 7 DeBakey ME. Carotid endarterectomy revisited. J Endovasc Surg 1996; 3 (1) 4
  • 8 Eastcott HH, Pickering GW, Rob CG. Reconstruction of internal carotid artery in a patient with intermittent attacks of hemiplegia. Lancet 1954; 267 (6846) 994-996
  • 9 Mathias K. Perkutane transluminale Katheterbehandlung supraaortaler Arterienobstruktionen. Angiology 1981; 3: 47-50
  • 10 Roubin GS, Yadav S, Iyer SS, Vitek J. Carotid stent-supported angioplasty: a neurovascular intervention to prevent stroke. Am J Cardiol 1996; 78 (3A): 8-12
  • 11 Ferguson GG, Eliasziw M, Barr HWK , et al; North American Symptomatic Carotid Endarterectomy Trial Collaborators. Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. N Engl J Med 1991; 325 (7) 445-453
  • 12 Randomised trial of endarterectomy for recently symptomatic carotid stenosis: final results of the MRC European Carotid Surgery Trial (ECST). Lancet 1998; 351 (9113) 1379-1387
  • 13 Walker MD, Marler JR, Goldstein M , et al. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study. Endarterectomy for asymptomatic carotid artery stenosis. J Am Med Assoc 1995; 273 (18) 1421-1428
  • 14 Rothwell PM, Goldstein LB. Carotid endarterectomy for asymptomatic carotid stenosis: asymptomatic carotid surgery trial. Stroke 2004; 35 (10) 2425-2427
  • 15 Halliday AW, Thomas D, Mansfield A ; Steering Committee. The Asymptomatic Carotid Surgery Trial (ACST). Rationale and design. Eur J Vasc Surg 1994; 8 (6) 703-710
  • 16 Gurm HS, Yadav JS, Fayad P , et al; SAPPHIRE Investigators. Long-term results of carotid stenting versus endarterectomy in high-risk patients. N Engl J Med 2008; 358 (15) 1572-1579
  • 17 Mas JL, Chatellier G, Beyssen B , et al; EVA-3S Investigators. Endarterectomy versus stenting in patients with symptomatic severe carotid stenosis. N Engl J Med 2006; 355 (16) 1660-1671
  • 18 Ringleb PA, Allenberg J, Brückmann H , et al; SPACE Collaborative Group. 30 day results from the SPACE trial of stent-protected angioplasty versus carotid endarterectomy in symptomatic patients: a randomised non-inferiority trial. Lancet 2006; 368 (9543) 1239-1247
  • 19 Ederle J, Dobson J, Featherstone RL , et al; International Carotid Stenting Study investigators. Carotid artery stenting compared with endarterectomy in patients with symptomatic carotid stenosis (International Carotid Stenting Study): an interim analysis of a randomised controlled trial. Lancet 2010; 375 (9719) 985-997
  • 20 White CJ. Carotid artery stenting. J Am Coll Cardiol 2014; 64 (7) 722-731
  • 21 Brott TG, Hobson II RW, Howard G , et al; CREST Investigators. Stenting versus endarterectomy for treatment of carotid-artery stenosis. N Engl J Med 2010; 363 (1) 11-23
  • 22 Gardner CM, Tan H, Hull EL , et al. Detection of lipid core coronary plaques in autopsy specimens with a novel catheter-based near-infrared spectroscopy system. JACC Cardiovasc Imaging 2008; 1 (5) 638-648
  • 23 Cassis LA, Lodder RA. Near-IR imaging of atheromas in living arterial tissue. Anal Chem 1993; 65 (9) 1247-1256
  • 24 Waxman S, Dixon SR, L'Allier P , et al. In vivo validation of a catheter-based near-infrared spectroscopy system for detection of lipid core coronary plaques: initial results of the SPECTACL study. JACC Cardiovasc Imaging 2009; 2 (7) 858-868
  • 25 Pu J, Mintz GS, Brilakis ES , et al. In vivo characterization of coronary plaques: novel findings from comparing greyscale and virtual histology intravascular ultrasound and near-infrared spectroscopy. Eur Heart J 2012; 33 (3) 372-383
  • 26 Horváth M, Hájek P, Štěchovsky C, Veselka J. Vulnerable plaque imaging and acute coronary syndrome. Cor Vasa 2014; 56: e362-e368
  • 27 Stěchovský C, Horváth M, Hájek P, Veselka J. Detection of vulnerable atherosclerotic plaque with near-infrared spectroscopy: a systematic review [in Czech]. Vnitr Lek 2014; 60 (4) 375-379
  • 28 Schnaudigel S, Gröschel K, Pilgram SM, Kastrup A. New brain lesions after carotid stenting versus carotid endarterectomy: a systematic review of the literature. Stroke 2008; 39 (6) 1911-1919
  • 29 Biasi GM, Froio A, Diethrich EB , et al. Carotid plaque echolucency increases the risk of stroke in carotid stenting: the Imaging in Carotid Angioplasty and Risk of Stroke (ICAROS) study. Circulation 2004; 110 (6) 756-762
  • 30 Yamada K, Kawasaki M, Yoshimura S , et al. Prediction of silent ischemic lesions after carotid artery stenting using integrated backscatter ultrasound and magnetic resonance imaging. Atherosclerosis 2010; 208 (1) 161-166
  • 31 van den Bouwhuijsen QJ, Vernooij MW, Hofman A, Krestin GP, van der Lugt A, Witteman JC. Determinants of magnetic resonance imaging detected carotid plaque components: the Rotterdam Study. Eur Heart J 2012; 33 (2) 221-229
  • 32 Millon A, Mathevet JL, Boussel L , et al. High-resolution magnetic resonance imaging of carotid atherosclerosis identifies vulnerable carotid plaques. J Vasc Surg 2013; 57 (4) 1046-1051.e2
  • 33 Saam T, Hetterich H, Hoffmann V , et al. Meta-analysis and systematic review of the predictive value of carotid plaque hemorrhage on cerebrovascular events by magnetic resonance imaging. J Am Coll Cardiol 2013; 62 (12) 1081-1091
  • 34 Uchiyama N, Misaki K, Mohri M , et al. Association between carotid plaque composition assessed by multidetector computed tomography and cerebral embolism after carotid stenting. Neuroradiology 2012; 54 (5) 487-493
  • 35 de Weert TT, Ouhlous M, Meijering E , et al. In vivo characterization and quantification of atherosclerotic carotid plaque components with multidetector computed tomography and histopathological correlation. Arterioscler Thromb Vasc Biol 2006; 26 (10) 2366-2372
  • 36 Spacek M, Veselka J. Carotid artery stenting - current status of the procedure. Arch Med Sci 2013; 9 (6) 1028-1034
  • 37 Kastrup A, Gröschel K, Krapf H, Brehm BR, Dichgans J, Schulz JB. Early outcome of carotid angioplasty and stenting with and without cerebral protection devices: a systematic review of the literature. Stroke 2003; 34 (3) 813-819
  • 38 Clair DG, Hopkins LN, Mehta M , et al; EMPiRE Clinical Study Investigators. Neuroprotection during carotid artery stenting using the GORE flow reversal system: 30-day outcomes in the EMPiRE Clinical Study. Catheter Cardiovasc Interv 2011; 77 (3) 420-429
  • 39 Parodi JC, Schönholz C, Parodi FE, Sicard G, Ferreira LM. Initial 200 cases of carotid artery stenting using a reversal-of-flow cerebral protection device. J Cardiovasc Surg (Torino) 2007; 48 (2) 117-124
  • 40 Bijuklic K, Wandler A, Hazizi F, Schofer J. The PROFI study (Prevention of Cerebral Embolization by Proximal Balloon Occlusion Compared to Filter Protection During Carotid Artery Stenting): a prospective randomized trial. J Am Coll Cardiol 2012; 59 (15) 1383-1389
  • 41 Raghunathan D, Abdel-Karim AR, Papayannis AC , et al. Relation between the presence and extent of coronary lipid core plaques detected by near-infrared spectroscopy with postpercutaneous coronary intervention myocardial infarction. Am J Cardiol 2011; 107 (11) 1613-1618
  • 42 Schultz CJ, Serruys PW, van der Ent M , et al. First-in-man clinical use of combined near-infrared spectroscopy and intravascular ultrasound: a potential key to predict distal embolization and no-reflow?. J Am Coll Cardiol 2010; 56 (4) 314
  • 43 Goldstein JA, Maini B, Dixon SR , et al. Detection of lipid-core plaques by intracoronary near-infrared spectroscopy identifies high risk of periprocedural myocardial infarction. Circ Cardiovasc Interv 2011; 4 (5) 429-437
  • 44 Goldstein JA, Grines C, Fischell T , et al. Coronary embolization following balloon dilation of lipid-core plaques. JACC Cardiovasc Imaging 2009; 2 (12) 1420-1424
  • 45 Saeed B, Banerjee S, Brilakis ES. Slow flow after stenting of a coronary lesion with a large lipid core plaque detected by near-infrared spectroscopy. EuroIntervention 2010; 6 (4) 545
  • 46 Horváth M, Hájek P, Muller JE , et al. First-in-man near-infrared spectroscopy proof of lipid-core embolization during carotid artery stenting. Arch Med Sci 2014; ; In press
  • 47 Timaran CH, Rosero EB, Martinez AE, Ilarraza A, Modrall JG, Clagett GP. Atherosclerotic plaque composition assessed by virtual histology intravascular ultrasound and cerebral embolization after carotid stenting. J Vasc Surg 2010; 52 (5) 1188-1194
  • 48 Sakhuja R, Suh WM, Jaffer FA, Jang IK. Residual thrombogenic substrate after rupture of a lipid-rich plaque: possible mechanism of acute stent thrombosis?. Circulation 2010; 122 (22) 2349-2350
  • 49 Stouffer GA. The Use of Near-Infrared Spectroscopy to Optimize Stent Length. J Invasive Cardiol 2013; 25: 19A
  • 50 Dixon SR, Grines CL, Munir A , et al. Analysis of target lesion length before coronary artery stenting using angiography and near-infrared spectroscopy versus angiography alone. Am J Cardiol 2012; 109 (1) 60-66
  • 51 Papayannis AC, Abdel-Karim AR, Mahmood A , et al. Association of coronary lipid core plaque with intrastent thrombus formation: a near-infrared spectroscopy and optical coherence tomography study. Catheter Cardiovasc Interv 2013; 81 (3) 488-493
  • 52 Bosiers M, de Donato G, Deloose K , et al. Does free cell area influence the outcome in carotid artery stenting?. Eur J Vasc Endovasc Surg 2007; 33 (2) 135-141 , discussion 142–143
  • 53 Schillinger M, Gschwendtner M, Reimers B , et al. Does carotid stent cell design matter?. Stroke 2008; 39 (3) 905-909
  • 54 Abbott AL. Medical (nonsurgical) intervention alone is now best for prevention of stroke associated with asymptomatic severe carotid stenosis: results of a systematic review and analysis. Stroke 2009; 40 (10) e573-e583
  • 55 Madder RD, Smith JL, Dixon SR, Goldstein JA. Composition of target lesions by near-infrared spectroscopy in patients with acute coronary syndrome versus stable angina. Circ Cardiovasc Interv 2012; 5 (1) 55-61
  • 56 Madder RD, Goldstein JA, Madden SP , et al. Detection by near-infrared spectroscopy of large lipid core plaques at culprit sites in patients with acute ST-segment elevation myocardial infarction. JACC Cardiovasc Interv 2013; 6 (8) 838-846
  • 57 Oemrawsingh RM, Cheng JM, García-García HM , et al; ATHEROREMO-NIRS Investigators. Near-infrared spectroscopy predicts cardiovascular outcome in patients with coronary artery disease. J Am Coll Cardiol 2014; 64 (23) 2510-2518