Recent Progress in the Development of Multitasking Directing Groups for Carbon–Hydrogen Activation Reactions

Huan Sun; Yong Huang

doi:10.1055/s-0035-1560169

Synlett, Table of Contents

Synlett 2015; 26(20): 2751-2762
DOI: 10.1055/s-0035-1560169

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Recent Progress in the Development of Multitasking Directing Groups for Carbon–Hydrogen Activation Reactions

Huan Sun

Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University, Shenzhen Graduate School, Shenzhen 518055, P. R. of China Email: huangyong@pkusz.edu.cn

,

Yong Huang*

Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University, Shenzhen Graduate School, Shenzhen 518055, P. R. of China Email: huangyong@pkusz.edu.cn

› Author Affiliations

Abstract

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Abstract

Selective carbon–hydrogen activation reactions can be accomplished in a predictive manner using directing auxiliaries. However, the majority of directing groups discovered to date are difficult to remove or to transform into a desirable functionality. Recently, removable, cleavable, and redox-neutral directing groups have been developed that significantly broaden both the substrate scope and synthetic diversity of carbon–hydrogen functionalization reactions. In this short account, we summarize recent progress we have made in the development of multitasking (removable, cleavable, redox-neutral, manipulable) directing groups for carbon–hydrogen activation reactions.

1 Introduction

2 Triazene

3 Nitrous Amide

4 Pyrazolidinone

5 N-Oxyacetamide

6 Conclusion

Key words

carbon–hydrogen activation - directing groups - multitasking functional groups - transition metals - substituted heterocycles

Full Text

References

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