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Synthesis 2015; 47(23): 3727-3732
DOI: 10.1055/s-0035-1560177
DOI: 10.1055/s-0035-1560177
paper
Synthesis of Imidazo[1,2-f]phenanthridines through Palladium-Catalyzed Intramolecular C–C Bond Formation
Further Information
Publication History
Received: 25 May 2015
Accepted after revision: 27 July 2015
Publication Date:
28 August 2015 (online)
Abstract
A simple and convenient approach is developed for the synthesis of the imidazo[1,2-f]phenanthridine framework via post-functionalization of imidazoles obtained through four-component reactions of 1,2-dicarbonyl compounds, anilines, aldehydes and ammonium acetate. The methodology involves palladium-catalyzed direct arylation through sp2 C–H activation. The reported procedure delivers good to high yields of imidazo[1,2-f]phenanthridine derivatives (58–94%) starting from readily available precursors.
Key words
C–H activation - C–C bond formation - direct arylation - palladium catalysis - imidazo[1,2-f]phenanthridinesSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1560177.
- Supporting Information
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