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Synthesis 2015; 47(22): 3561-3572
DOI: 10.1055/s-0035-1560183
DOI: 10.1055/s-0035-1560183
paper
Regioselective C2- and C8-Acylation of 5,11-Dihydroindolo[3,2-b]carbazoles and the Synthesis of Their 2,8-Bis(quinoxalinyl) Derivatives
Further Information
Publication History
Received: 20 June 2015
Accepted after revision: 27 July 2015
Publication Date:
27 August 2015 (online)
Abstract
An efficient approach for the double acetylation of 5,11-dihexyl-6,12-di(hetero)aryl-substituted 5,11-dihydroindolo[3,2-b]carbazoles with acetic anhydride in the presence of boron trifluoride etherate has been developed, thus affording the corresponding 2,8-diacetyl derivatives in good yields. A similar acylation has been shown to occur by the reaction of anhydrides of other carboxylic acids. Oxidation of the obtained 2,8-diacetyl derivatives with selenium dioxide takes place on heating or under microwave irradiation, thus resulting in the formation of the corresponding 2,8-diglyoxals. The latter proved to react with aromatic o-diamines to afford new indolo[3,2-b]carbazoles bearing quinoxalinyl fragments at C-2 and C-8. Major optical properties of quinoxaline-containing indolo[3,2-b]carbazoles have been measured.
Key words
5,11-dihydroindolo[3,2-b]carbazoles - acylation - 2-arylglyoxals - quinoxalines - ladder-type heteroacenesSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1560183.
- Supporting Information
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