New and Efficient Synthesis of 2,3,4-Trisubstituted 2H-Pyrrolo[3,4-c]quinolines via a MCR/Staudinger/Aza-Wittig Sequence

Feng Qu; Ruo-Fei Hu; Le Gao; Jing Wu; Xiao-Hong Cheng; Song Wang; Ping He

doi:10.1055/s-0035-1560208

Synthesis, Inhaltsverzeichnis

Synthesis 2015; 47(23): 3701-3710
DOI: 10.1055/s-0035-1560208

paper

New and Efficient Synthesis of 2,3,4-Trisubstituted 2H-Pyrrolo[3,4-c]quinolines via a MCR/Staudinger/Aza-Wittig Sequence

Autor*innen

Feng Qu

^aCollege of Chemical Engineering and Food Science, Hubei University of Arts and Science, Xiangyang, 441053, Hubei Province, P. R. of China
Ruo-Fei Hu

^aCollege of Chemical Engineering and Food Science, Hubei University of Arts and Science, Xiangyang, 441053, Hubei Province, P. R. of China
Le Gao

^aCollege of Chemical Engineering and Food Science, Hubei University of Arts and Science, Xiangyang, 441053, Hubei Province, P. R. of China
Jing Wu

^aCollege of Chemical Engineering and Food Science, Hubei University of Arts and Science, Xiangyang, 441053, Hubei Province, P. R. of China
Xiao-Hong Cheng

^bHubei Key Laboratory of Low Dimensional Optoelectronic Materials and Devices, Hubei University of Arts and Science, Xiangyang, 441053, Hubei Province, P. R. of China
Song Wang

^bHubei Key Laboratory of Low Dimensional Optoelectronic Materials and Devices, Hubei University of Arts and Science, Xiangyang, 441053, Hubei Province, P. R. of China
Ping He*

^aCollege of Chemical Engineering and Food Science, Hubei University of Arts and Science, Xiangyang, 441053, Hubei Province, P. R. of China

^bHubei Key Laboratory of Low Dimensional Optoelectronic Materials and Devices, Hubei University of Arts and Science, Xiangyang, 441053, Hubei Province, P. R. of China

Abstract

Alle Artikel dieser Rubrik

Abstract

A new and efficient method for the construction of 2,3,4-trisubstituted 2H-pyrrolo[3,4-c]quinoline derivatives was developed. Starting from easily accessible 2-azidobenzaldehyde, nitromethane, 1,3-dicarbonyl compounds, and various amines gave the multicomponent reaction (MCR) products, 1-substituted 3-acyl-4-(2-azidophenyl)-2-methyl-1H-pyrroles, that underwent Staudinger/aza-Wittig cyclization of in the presence of triphenylphosphine to give the final products.

Key words

2H-pyrrolo[3,4-c]quinolones - multicomponent reaction - azide - aza-Wittig reaction - iminophosphorane

Volltext

Referenzen

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Zusatzmaterial

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