N-Substituted Formamides as C₁-Sources for the Synthesis of Benzimidazole and Benzothiazole Derivatives by Using Zinc Catalysts

Abstract

An efficient and convenient one-pot protocol has been developed for the synthesis of a variety of benzimidazole, benzoxazole, and benzothiazole derivatives. This novel approach uses various o-phenylenediamines and N-substituted formamides (C₁ sources) in a zinc-catalyzed cyclization in the presence of poly(methylhydrosiloxane) to afford the corresponding derivatives as sole products in moderate to excellent yields.

Key words

formamides - benzenediamines - cyclizations - heterocycles - zinc - catalysis

• References

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