Synthesis 2016; 48(06): 906-916
DOI: 10.1055/s-0035-1560404
paper
© Georg Thieme Verlag Stuttgart · New York

A Short Access to Symmetrically α,α-Disubstituted α-Amino Acids from Acyl Cyanohydrins

Fatma Boukattaya
a   LUNAM Université, Université du Maine, CNRS UMR 6283, Institut des Molécules et Matériaux du Mans (IMMM), 72085 Le Mans Cedex 09, France   Email: philippe.bertus@univ-lemans.fr
b   Laboratory of Applied Chemistry HCGP, Faculty of Science, University of Sfax, 3000 Sfax, Tunisia
,
Julien Caillé
a   LUNAM Université, Université du Maine, CNRS UMR 6283, Institut des Molécules et Matériaux du Mans (IMMM), 72085 Le Mans Cedex 09, France   Email: philippe.bertus@univ-lemans.fr
,
Houcine Ammar
b   Laboratory of Applied Chemistry HCGP, Faculty of Science, University of Sfax, 3000 Sfax, Tunisia
,
Florian Rouzier
a   LUNAM Université, Université du Maine, CNRS UMR 6283, Institut des Molécules et Matériaux du Mans (IMMM), 72085 Le Mans Cedex 09, France   Email: philippe.bertus@univ-lemans.fr
,
Fabien Boeda
a   LUNAM Université, Université du Maine, CNRS UMR 6283, Institut des Molécules et Matériaux du Mans (IMMM), 72085 Le Mans Cedex 09, France   Email: philippe.bertus@univ-lemans.fr
,
Morwenna S. M. Pearson-Long
a   LUNAM Université, Université du Maine, CNRS UMR 6283, Institut des Molécules et Matériaux du Mans (IMMM), 72085 Le Mans Cedex 09, France   Email: philippe.bertus@univ-lemans.fr
,
Philippe Bertus*
a   LUNAM Université, Université du Maine, CNRS UMR 6283, Institut des Molécules et Matériaux du Mans (IMMM), 72085 Le Mans Cedex 09, France   Email: philippe.bertus@univ-lemans.fr
› Author Affiliations
Further Information

Publication History

Received: 23 October 2015

Accepted after revision: 02 December 2015

Publication Date:
13 January 2016 (online)


Abstract

A straightforward synthesis of symmetrically α,α-disubstituted α-amino acids is presented. The key step of this process relies on the efficient double addition of Grignard reagents to acyl cyanohydrins to provide N-acyl amino alcohols selectively in good yields. The chemoselectivity of the reaction was modulated by the nature of the acyl moiety. Eleven amino acids were prepared, including the particularly simple divinylglycine, which is not easily accessible by using conventional methods.

Supporting Information

 
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