Potassium-Exchanged Zirconium Hydrogen Phosphate [α-Zr(KPO4)2]-Catalyzed Synthesis of 2-Amino-4H-pyran Derivatives under Solvent-Free Conditions

Ornelio Rosati; Azzurra Pelosi; Andrea Temperini; Vittorio Pace; Massimo Curini

doi:10.1055/s-0035-1560411

Synthesis, Inhaltsverzeichnis

Synthesis 2016; 48(10): 1533-1540
DOI: 10.1055/s-0035-1560411

paper

Potassium-Exchanged Zirconium Hydrogen Phosphate [α-Zr(KPO₄)₂]-Catalyzed Synthesis of 2-Amino-4H-pyran Derivatives under Solvent-Free Conditions

Ornelio Rosati*

^aDipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia, Via del Liceo 1, 06123 Perugia, Italy eMail: ornelio.rosati@unipg.it

,

Azzurra Pelosi

^aDipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia, Via del Liceo 1, 06123 Perugia, Italy eMail: ornelio.rosati@unipg.it

,

Andrea Temperini

^aDipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia, Via del Liceo 1, 06123 Perugia, Italy eMail: ornelio.rosati@unipg.it

,

Vittorio Pace

^bDepartment of Pharmaceutical Chemistry, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria

,

Massimo Curini

^aDipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia, Via del Liceo 1, 06123 Perugia, Italy eMail: ornelio.rosati@unipg.it

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Abstract

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Abstract

A high-yielding, one-pot, three-component synthesis of functionalized 2-amino-4H-pyrans from β-dicarbonyl compounds, activated cyanomethylene compounds, and aldehydes, mediated by potassium-exchanged zirconium hydrogen phosphate [α-Zr(KPO₄)₂], is reported. The protocol shows excellent versatility, as it can be applied to aromatic, aliphatic, or α,β-unsaturated aldehydes under solvent-free conditions.

Key words

pyrans - amines - heterogeneous catalysis - solvent-free synthesis - multicomponent reactions - cyclizations

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References

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