Synthesis of Quinazolines and Dihydroquinazolines: o-Iodoxybenzoic Acid Mediated Tandem Reaction of o-Aminobenzylamine with Aldehydes

Abstract

We have demonstrated a facile synthesis of diversely substituted quinazolines and 3,4-dihydroquinazolines through the o-iodoxybenzoic acid (IBX) mediated tandem reaction of readily available o-aminobenzylamine and aldehydes. The yield of the reactions generally ranged from 70% to 95%. This mild protocol provides an efficient strategy toward the synthesis of these classes of heterocycles.

Key words

quinazolines - dihydroquinazolines - o-iodoxybenzoic acid - o-aminobenzylamine - aldehydes

• References

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