Remarkably Selective Formation of Allenyl and Dienyl Alcohols via Ni-Catalyzed Coupling Reaction of Conjugated Enyne, Aldehyde, and Organozinc Reagents

Abstract

A nickel catalyst promotes the multi-component reactions (MCRs) of conjugated enynes, aldehydes, and organozinc reagents to form unsaturated alcohols. Ligand effects dramatically control the regio­selectivity in these Ni-catalyzed MCRs, leading to the selective formation of allenyl alcohols and conjugated dienyl alcohols.

Key words

nickel - multi-component reaction - organozinc reagent - conjugated enyne - allenyl alcohol - dienyl alcohol

• References

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Electronic and steric parameters of NHC ligands are reported:
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