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Synthesis 2015; 47(23): 3751-3757
DOI: 10.1055/s-0035-1560473
DOI: 10.1055/s-0035-1560473
paper
Synthesis of α-Hydroxycarboxylic Acid Anilides via Copper-Catalyzed C–N Coupling of α-Hydroxyamides with Aryl Halides
Weitere Informationen
Publikationsverlauf
Received: 21. Juni 2015
Accepted after revision: 18. August 2015
Publikationsdatum:
09. September 2015 (online)
![](https://www.thieme-connect.de/media/synthesis/201523/lookinside/thumbnails/ss-2015-h0391-op_10-1055_s-0035-1560473-1.jpg)
Abstract
The synthesis of highly important α-hydroxycarboxylic acid anilides via copper-catalyzed chemoselective C–N coupling reactions of α-hydroxyamides and aryl halides is described. This highly selective N-arylation process demonstrates wide substrate scope, cost savings and easy operation. In addition, the chirality of l-3-phenyllactamide is preserved during the reaction.
Key words
α-hydroxycarboxylic acid anilides - copper - cross-coupling - α-hydroxyamides - catalysis - chemoselectivitySupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1560473.
- Supporting Information
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