A Facile Linking of the Pyrrole Ring with Functionalized 3(2H)-Furanone Moieties

Abstract

The CN-functionalized pyrrole(indole)-3(2H)-furanone derivatives are readily synthesized via the domino reaction of diverse pyrrole(indole) carboxylic acids with tertiary cyanopropargylic alcohols (Et₃N, MeCN, MW reactor, 100 °C, 1.2 atm) in up to 93% yield.

Key words

pyrrole(indole)-2-carboxylic acids - tertiary cyanopropargylic alcohols - domino reaction - cyclization - pyrrole(indole)-3(2H)-furanone derivatives

• References

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