Synthesis of Decytospolide A, B and Their C-3 Epimers Using Stereoselective­ Oxypalladation

Abstract

Stereoselective synthesis of decytospolide A and B and their C-3 epimers, which have a 2,6-cis-tetrahydropyran ring, has been achieved in high stereoselectivity and yield. The oxypalladation of single diastereomers of 6-(benzyloxy)-7-hydroxydodec-2-enyl 2-naphthoates was optimized to give products with a 2,6-cis-tetrahydropyran ring with high diastereoselectivity and yield.

Key words

natural products - palladium - antitumor agents - cyclization - total synthesis

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