Two Novel and Simple Approaches to ‘CD45 Protein Tyrosine Phosphatase Inhibitor’ (Z)-Pulchellalactam and Derivatives

E. Anselmi; K. Cherry; C. Maaliki; S. Inack Ngi; A. Duchêne; J. Thibonnet; M. Abarbri

doi:10.1055/s-0035-1561375

Synthesis, Table of Contents

Synthesis 2016; 48(09): 1407-1413
DOI: 10.1055/s-0035-1561375

paper

Two Novel and Simple Approaches to ‘CD45 Protein Tyrosine Phosphatase Inhibitor’ (Z)-Pulchellalactam and Derivatives

E. Anselmi

^aLaboratoire d’Infectiologie et Santé Publique, UMR 1282 Université François Rabelais/INRA, UFR Sciences et Techniques, Parc de Grandmont, 37200 Tours, France Email: mohamed.abarbri@univ-tours.fr

,

K. Cherry

^bLaboratoire de Matériaux, Catalyse, Environnement et Méthodes Analytiques (MCEMA), Université Libanaise, Faculté des Sciences, Section I, Hadath, Lebanon

,

C. Maaliki

^aLaboratoire d’Infectiologie et Santé Publique, UMR 1282 Université François Rabelais/INRA, UFR Sciences et Techniques, Parc de Grandmont, 37200 Tours, France Email: mohamed.abarbri@univ-tours.fr

,

S. Inack Ngi

^aLaboratoire d’Infectiologie et Santé Publique, UMR 1282 Université François Rabelais/INRA, UFR Sciences et Techniques, Parc de Grandmont, 37200 Tours, France Email: mohamed.abarbri@univ-tours.fr

,

A. Duchêne

^aLaboratoire d’Infectiologie et Santé Publique, UMR 1282 Université François Rabelais/INRA, UFR Sciences et Techniques, Parc de Grandmont, 37200 Tours, France Email: mohamed.abarbri@univ-tours.fr

,

J. Thibonnet

^aLaboratoire d’Infectiologie et Santé Publique, UMR 1282 Université François Rabelais/INRA, UFR Sciences et Techniques, Parc de Grandmont, 37200 Tours, France Email: mohamed.abarbri@univ-tours.fr

,

M. Abarbri*

^aLaboratoire d’Infectiologie et Santé Publique, UMR 1282 Université François Rabelais/INRA, UFR Sciences et Techniques, Parc de Grandmont, 37200 Tours, France Email: mohamed.abarbri@univ-tours.fr

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Abstract

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Abstract

Two novel routes to the naturally occurring CD45 protein tyrosine phosphatase inhibitor, (Z)-pulchellalactam, and its derivatives are reported in two steps starting from dienoic acids through electrophilic cyclisation. This methodology proceeds regio- and stereoselectively, and can be used to design a library of synthetic pulchellalactam analogues.

Key words

dienoic acids - dienamides - iodocyclization - electrophilic cyclization - pulchellalactam

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References

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