Concise Synthesis of Cinnamtannin A2 from Dimeric Epicatechin Electrophile and Nucleophile Prepared by Zn(OTf)₂-Mediated Self-Condensation

◊ These authors contributed equally

Abstract

The synthesis of cinnamtannin A2 from dimeric epicatechin nucleophile and electrophile was accomplished. Dimeric epicatechin nucleophile was prepared directly by reduction of the C-4′′ 1-ethoxy­ethoxy group of the electrophile which was previously synthesized by us.

Key words

phenols - Lewis acids - oligomerization - natural products - stereoselective synthesis

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