Synthesis 2016; 48(13): 2069-2078
DOI: 10.1055/s-0035-1561427
paper
© Georg Thieme Verlag Stuttgart · New York

Metal-Free Amidation of Acids with Formamides and T3P®

Linda Bannwart
Chemistry Process R&D, Actelion Pharmaceuticals Ltd., Gewerbestrasse 16, 4123 Allschwil, Switzerland   Email: simone.tortoioli@actelion.com
,
Stefan Abele
Chemistry Process R&D, Actelion Pharmaceuticals Ltd., Gewerbestrasse 16, 4123 Allschwil, Switzerland   Email: simone.tortoioli@actelion.com
,
Simone Tortoioli*
Chemistry Process R&D, Actelion Pharmaceuticals Ltd., Gewerbestrasse 16, 4123 Allschwil, Switzerland   Email: simone.tortoioli@actelion.com
› Author Affiliations
Further Information

Publication History

Received: 12 February 2016

Accepted after revision: 07 March 2016

Publication Date:
12 April 2016 (online)


This paper is dedicated to the memory of the inspirational late Professor Vincenzo Caia.

Abstract

A new, simple and metal-free method for the direct formation of dialkylamides from carboxylic acids employing N,N-dialkylform­amides as amine source is described. The one-pot reaction is promoted by propylphosphonic anhydride (T3P®) in the presence of 0.5 equivalents of HCl.

Supporting Information

 
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