Synthesis 2016; 48(21): 3785-3793
DOI: 10.1055/s-0035-1561472
paper
© Georg Thieme Verlag Stuttgart · New York

N-Bromosuccinimide-Mediated Synthesis of Substituted Quinoxalines

Chieh-Kai Chan
Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung 80708, Taiwan, Republic of China   eMail: mychang@kmu.edu.tw
,
Meng-Yang Chang*
Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung 80708, Taiwan, Republic of China   eMail: mychang@kmu.edu.tw
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Publikationsverlauf

Received: 25. März 2016

Accepted after revision: 13. Mai 2016

Publikationsdatum:
24. Juni 2016 (online)


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Abstract

An efficient and simple N-bromosuccinimide-mediated two-step synthesis of substituted quinoxalines from 1,2-diarylacetylenes and 1,2-diaminobenzenes in boiling AcOH, during a one-pot procedure has been developed. All the structures of the substituted quinoxalines were confirmed, some by single-crystal X-ray crystallography. Possible reaction pathways were discussed, and some data were matched with the previous work.

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