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Synthesis 2016; 48(23): 4269-4277
DOI: 10.1055/s-0035-1561489
DOI: 10.1055/s-0035-1561489
paper
Efficient Preparation of Imidazo[1,5-a]pyridine-1-carboxylic Acids
Weitere Informationen
Publikationsverlauf
Received: 30. März 2016
Accepted after revision: 31. Mai 2016
Publikationsdatum:
27. Juli 2016 (online)
Abstract
We report a novel and efficient approach to the synthesis of imidazo[1,5-a]pyridine-1-carboxylic acids. By using the reaction of 2-(aminomethyl)pyridine with acyl chlorides followed by one-pot treatment with trifluoroacetic anhydride, 2,2,2-trifluoro-1-imidazo[1,5-a]pyridin-1-ylethanones were obtained, which were then converted into imidazo[1,5-a]pyridine-1-carboxylic acids in high preparative yields through haloform cleavage.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1561489.
- Supporting Information
Primary Data
- Primary data for this article are available online at http://www.thieme-connect.com/products/ejournals/journal/10.1055/s-00000084 and can be cited using the following DOI: 10.4125/pd0080th.
- Primary Data
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