Organocatalytic Multicomponent Reactions of 1,3-Dicarbonyls for the Synthesis of Enantioenriched Heterocycles

^‡ Both authors contributed equally to this study.

Abstract

In this feature article, a general perspective of the research program aimed towards the preparation of polycyclic heterocycles by the means of enantioselective organocatalytic multicomponent reactions is presented. Guidelines for reaction design, including the selection of substrates and organocatalysts are discussed. For all transformations, scope and limitations are presented, along with post-functionalization to afford diversified heterocyclic scaffolds.

1 Introduction

2 Type I Products: 1,4,5,6-Tetrahydropyridines

3 Type II Products: 1,2,3,4-Tetrahydropyridines

4 Type III Products: Bridged Perhydropyridines

5 Conclusion and Perspective

Key words

1,3-dicarbonyls - enantioselectivity - heterocycles - Michael addition - multicomponent reactions - organocatalysis

• References

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