Zn/MeOH-Mediated Practical and Easy Detritylation of Protected 1-Trityltetrazoles

Cherif Behloul; Kenza Bouchelouche; Yasmine Hadji; Saadia Benseghir; David Guijarro; Carmen Nájera; Miguel Yus

doi:10.1055/s-0035-1561609

Synthesis, Inhaltsverzeichnis

Synthesis 2016; 48(15): 2455-2460
DOI: 10.1055/s-0035-1561609

paper

Zn/MeOH-Mediated Practical and Easy Detritylation of Protected 1-Trityltetrazoles

Cherif Behloul*

^aLaboratoire des Produits Naturels d’origine Végétale et de Synthèse Organique, Université des Frères Mentouri-Constantine, 25000, Algérie eMail: afiza72@gmail.com

,

Kenza Bouchelouche

^aLaboratoire des Produits Naturels d’origine Végétale et de Synthèse Organique, Université des Frères Mentouri-Constantine, 25000, Algérie eMail: afiza72@gmail.com

,

Yasmine Hadji

^aLaboratoire des Produits Naturels d’origine Végétale et de Synthèse Organique, Université des Frères Mentouri-Constantine, 25000, Algérie eMail: afiza72@gmail.com

,

Saadia Benseghir

^aLaboratoire des Produits Naturels d’origine Végétale et de Synthèse Organique, Université des Frères Mentouri-Constantine, 25000, Algérie eMail: afiza72@gmail.com

,

David Guijarro

^bDepartamento de Química Orgánica, Facultad de Ciencias, Universidad de Alicante, Apdo. 99, 03080 Alicante, Spain

^cInstituto de Síntesis Orgánica (ISO), Universidad de Alicante, Apdo. 99, 03080 Alicante, Spain

,

Carmen Nájera

^bDepartamento de Química Orgánica, Facultad de Ciencias, Universidad de Alicante, Apdo. 99, 03080 Alicante, Spain

^dCentro de Innovación en Química Avanzada (ORFEO-CINQA), Universidad de Alicante, Apdo. 99, 03080 Alicante, Spain

,

Miguel Yus

^bDepartamento de Química Orgánica, Facultad de Ciencias, Universidad de Alicante, Apdo. 99, 03080 Alicante, Spain

^dCentro de Innovación en Química Avanzada (ORFEO-CINQA), Universidad de Alicante, Apdo. 99, 03080 Alicante, Spain

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Abstract

Alle Artikel dieser Rubrik

Dedicated to the memory of Professors Rafael Usón and Tsutomu Katsuki

Abstract

A practical and low-cost method for the detritylation of 1-titryltetrazoles using zinc and methanol is described. This procedure is versatile and efficient in the deprotection of several protected tetrazoles bearing aliphatic, aromatic, and heteroaromatic substituents, as well as some functional groups, without decomposition of the tetrazole ring.

Keywords

tetrazoles - zinc/methanol - detritylation - reductive cleavage

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Referenzen

References

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